Mechanisms of apoptotic phosphatidylserine exposure

Guillermo Mariño, Guido Kroemer

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    152 Citations (Scopus)

    Résumé

    It has been a long-standing enigma which scramblase causes phosphatidylserine residues to be exposed on the surface of apoptotic cells, thereby facilitating the phagocytic recognition, engulfment and destruction of apoptotic corpses. In a recent paper in Science, Nagata and coworkers reveal that the scramblases Xkr8 and its C. elegans ortholog, CED-8, are activated by caspase cleavage in apoptotic cells.

    langue originaleAnglais
    Pages (de - à)1247-1248
    Nombre de pages2
    journalCell Research
    Volume23
    Numéro de publication11
    Les DOIs
    étatPublié - 1 nov. 2013

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