TY - JOUR
T1 - Metabolic Cancer Biology
T2 - Structural-based analysis of cancer as a metabolic disease, new sights and opportunities for disease treatment
AU - Masoudi-Nejad, Ali
AU - Asgari, Yazdan
N1 - Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - The cancer cell metabolism or the Warburg effect discovery goes back to 1924 when, for the first time Otto Warburg observed, in contrast to the normal cells, cancer cells have different metabolism. With the initiation of high throughput technologies and computational systems biology, cancer cell metabolism renaissances and many attempts were performed to revise the Warburg effect. The development of experimental and analytical tools which generate high-throughput biological data including lots of information could lead to application of computational models in biological discovery and clinical medicine especially for cancer. Due to the recent availability of tissue-specific reconstructed models, new opportunities in studying metabolic alteration in various kinds of cancers open up. Structural approaches at genome-scale levels seem to be suitable for developing diagnostic and prognostic molecular signatures, as well as in identifying new drug targets. In this review, we have considered these recent advances in structural-based analysis of cancer as a metabolic disease view. Two different structural approaches have been described here: topological and constraint-based methods. The ultimate goal of this type of systems analysis is not only the discovery of novel drug targets but also the development of new systems-based therapy strategies.
AB - The cancer cell metabolism or the Warburg effect discovery goes back to 1924 when, for the first time Otto Warburg observed, in contrast to the normal cells, cancer cells have different metabolism. With the initiation of high throughput technologies and computational systems biology, cancer cell metabolism renaissances and many attempts were performed to revise the Warburg effect. The development of experimental and analytical tools which generate high-throughput biological data including lots of information could lead to application of computational models in biological discovery and clinical medicine especially for cancer. Due to the recent availability of tissue-specific reconstructed models, new opportunities in studying metabolic alteration in various kinds of cancers open up. Structural approaches at genome-scale levels seem to be suitable for developing diagnostic and prognostic molecular signatures, as well as in identifying new drug targets. In this review, we have considered these recent advances in structural-based analysis of cancer as a metabolic disease view. Two different structural approaches have been described here: topological and constraint-based methods. The ultimate goal of this type of systems analysis is not only the discovery of novel drug targets but also the development of new systems-based therapy strategies.
KW - Cancer
KW - Cancer treatment
KW - Flux balance analysis
KW - Genome-scale modeling
KW - Metabolic networks
KW - Topological analysis
KW - Warburg effect
UR - http://www.scopus.com/inward/record.url?scp=84919660482&partnerID=8YFLogxK
U2 - 10.1016/j.semcancer.2014.01.007
DO - 10.1016/j.semcancer.2014.01.007
M3 - Review article
C2 - 24495661
AN - SCOPUS:84919660482
SN - 1044-579X
VL - 30
SP - 21
EP - 29
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
ER -