Metastatic renal cell carcinoma with occult primary: a multicenter prospective cohort

Nicolas Jacquin; Ronan Flippot; Julien Masliah-Planchon; Guillaume Grisay; Riwan Brillet; Célia Dupain; Maud Kamal; Isabelle Guillou; Nadège Gruel; Nicolas Servant; Pierre Gestraud; Jennifer Wong; Vincent Cockenpot; Andreia Goncalves; Janick Selves; Hélène Blons; Etienne Rouleau; Olivier Delattre; Claire Gervais; Christophe Le Tourneau; Ivan Bièche; Yves Allory; Laurence Albigès; Sarah Watson

doi:10.1038/s41698-024-00648-0

Metastatic renal cell carcinoma with occult primary: a multicenter prospective cohort

Nicolas Jacquin, Ronan Flippot, Julien Masliah-Planchon, Guillaume Grisay, Riwan Brillet, Célia Dupain, Maud Kamal, Isabelle Guillou, Nadège Gruel, Nicolas Servant, Pierre Gestraud, Jennifer Wong, Vincent Cockenpot, Andreia Goncalves, Janick Selves, Hélène Blons, Etienne Rouleau, Olivier Delattre, Claire Gervais, Christophe Le TourneauIvan Bièche, Yves Allory, Laurence Albigès, Sarah Watson

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

Metastatic carcinoma of presumed renal origin (rCUP) has recently emerged as a new entity within the heterogeneous entity of Cancers of Unknown Primary (CUP) but their biological features and optimal therapeutic management remain unknown. We report the molecular characteristics and clinical outcome of a series of 25 rCUP prospectively identified within the French National Multidisciplinary Tumor Board for CUP. This cohort strongly suggests that rCUP share similarities with common RCC subtypes and benefit from renal-tailored systemic treatment. This study highlights the importance of integrating clinical and molecular data for optimal diagnosis and management of CUP.

langue originale	Anglais
Numéro d'article	147
journal	npj Precision Oncology
Volume	8
Numéro de publication	1
Les DOIs	https://doi.org/10.1038/s41698-024-00648-0
état	Publié - 1 déc. 2024

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10.1038/s41698-024-00648-0

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Jacquin, N., Flippot, R., Masliah-Planchon, J., Grisay, G., Brillet, R., Dupain, C., Kamal, M., Guillou, I., Gruel, N., Servant, N., Gestraud, P., Wong, J., Cockenpot, V., Goncalves, A., Selves, J., Blons, H., Rouleau, E., Delattre, O., Gervais, C., ... Watson, S. (2024). Metastatic renal cell carcinoma with occult primary: a multicenter prospective cohort. npj Precision Oncology, 8(1), Article 147. https://doi.org/10.1038/s41698-024-00648-0

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title = "Metastatic renal cell carcinoma with occult primary: a multicenter prospective cohort",

abstract = "Metastatic carcinoma of presumed renal origin (rCUP) has recently emerged as a new entity within the heterogeneous entity of Cancers of Unknown Primary (CUP) but their biological features and optimal therapeutic management remain unknown. We report the molecular characteristics and clinical outcome of a series of 25 rCUP prospectively identified within the French National Multidisciplinary Tumor Board for CUP. This cohort strongly suggests that rCUP share similarities with common RCC subtypes and benefit from renal-tailored systemic treatment. This study highlights the importance of integrating clinical and molecular data for optimal diagnosis and management of CUP.",

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Jacquin, N, Flippot, R, Masliah-Planchon, J, Grisay, G, Brillet, R, Dupain, C, Kamal, M, Guillou, I, Gruel, N, Servant, N, Gestraud, P, Wong, J, Cockenpot, V, Goncalves, A, Selves, J, Blons, H, Rouleau, E, Delattre, O, Gervais, C, Le Tourneau, C, Bièche, I, Allory, Y, Albigès, L & Watson, S 2024, 'Metastatic renal cell carcinoma with occult primary: a multicenter prospective cohort', npj Precision Oncology, VOL. 8, Numéro 1, 147. https://doi.org/10.1038/s41698-024-00648-0

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T1 - Metastatic renal cell carcinoma with occult primary

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AU - Jacquin, Nicolas

AU - Flippot, Ronan

AU - Masliah-Planchon, Julien

AU - Grisay, Guillaume

AU - Brillet, Riwan

AU - Dupain, Célia

AU - Kamal, Maud

AU - Guillou, Isabelle

AU - Gruel, Nadège

AU - Servant, Nicolas

AU - Gestraud, Pierre

AU - Wong, Jennifer

AU - Cockenpot, Vincent

AU - Goncalves, Andreia

AU - Selves, Janick

AU - Blons, Hélène

AU - Rouleau, Etienne

AU - Delattre, Olivier

AU - Gervais, Claire

AU - Le Tourneau, Christophe

AU - Bièche, Ivan

AU - Allory, Yves

AU - Albigès, Laurence

AU - Watson, Sarah

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