TY - JOUR
T1 - Metformin impacts the prognosis of cancer patients with type 2 diabetes
AU - Aldea, Mihaela
AU - Craciun, Lucian
AU - Crivii, Carmen
PY - 2014/1/1
Y1 - 2014/1/1
N2 - A long term complication of diabetes is the increased susceptibility to develop various malignancies and also to negatively impact the progression of cancer. However, metformin, widely used in the treatment of type II diabetes, seems to impact the outcome of several types of cancer, in terms of overall survival, disease-free survival or rates of recurrences. Metformin might impact cancer through various mechanisms, including reduced insulin and insulin-like growth factor-mediated signaling as well as modulation of inflammation and adipokine activity. This review presents the clinical studies that deal with the prognostic impact of metformin on cancer and discuss the possible reasons for why certain types of cancer are affected by anti-diabetic therapy. In addition, it tries to integrate the preclinical and clinical evidence into guidelines for future prospective clinical studies.
AB - A long term complication of diabetes is the increased susceptibility to develop various malignancies and also to negatively impact the progression of cancer. However, metformin, widely used in the treatment of type II diabetes, seems to impact the outcome of several types of cancer, in terms of overall survival, disease-free survival or rates of recurrences. Metformin might impact cancer through various mechanisms, including reduced insulin and insulin-like growth factor-mediated signaling as well as modulation of inflammation and adipokine activity. This review presents the clinical studies that deal with the prognostic impact of metformin on cancer and discuss the possible reasons for why certain types of cancer are affected by anti-diabetic therapy. In addition, it tries to integrate the preclinical and clinical evidence into guidelines for future prospective clinical studies.
KW - Cancer
KW - Diabetes mellitus
KW - Metformin
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=84902362284&partnerID=8YFLogxK
U2 - 10.2478/rjdnmd-2014-0016
DO - 10.2478/rjdnmd-2014-0016
M3 - Review article
AN - SCOPUS:84902362284
SN - 1583-8609
VL - 21
SP - 111
EP - 120
JO - Romanian Journal of Diabetes, Nutrition and Metabolic Diseases
JF - Romanian Journal of Diabetes, Nutrition and Metabolic Diseases
IS - 2
ER -