@inbook{f8e73f87d57e4e06bd472a9daafed6f5,
title = "Methods to edit T cells for cancer immunotherapy",
abstract = "This chapter summarizes the recent findings regarding the development of gene-editing technologies applied to adoptive T cell immunotherapy for cancer. The emerging tools and strategies described below enable the generation of a tailored system, establishing T cells as an advanced biomaterial with redirected specificities that are both programmable and inducible and establish long-term antitumor potential. These reviewed techniques and strategies are implemented with an optimized protocol for the generation of CAR-T cells using lentiviral gene transfer.",
keywords = "Adoptive transfer, Cancer immunotherapy, T cells engineering",
author = "Francesca Lucibello and Silvia Menegatti and Laurie Menger",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = jan,
day = "1",
doi = "10.1016/bs.mie.2019.05.048",
language = "English",
isbn = "9780128186732",
series = "Methods in Enzymology",
publisher = "Academic Press Inc.",
pages = "107--135",
editor = "Lorenzo Galluzzi and Nils-Petter Rudqvist",
booktitle = "Tumor Immunology and Immunotherapy - Cellular Methods Part A",
}