MGL_3741 gene contributes to pathogenicity of Malassezia globosa in pityriasis versicolor

Sanaz Aghaei Gharehbolagh, Parivash Kordbacheh, Seyed Jamal Hashemi, Roshanak Daie Ghazvini, Yazdan Asgari, Setareh Agha Kuchak Afshari, Seyedmojtaba Seyedmousavi, Sassan Rezaie

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

9 Citations (Scopus)

Résumé

Dihydroxyacid dehydratase (DHAD) is a key enzyme in biosynthetic pathway of isoleucine and valine. This pathway is absent in human but exists in various organisms such as fungi. Using RNA-seq analysis in this study, we identified MGL_3741gene which encodes DHAD protein in Malassezia globosa (M. globosa). Furthermore, we found that mentioned gene is homologous to the Ustilago maydis, Saccharomyces cerevisiae, Aspergillus flavus, and Aspergillus fumigatus ILV3P. For understanding the probable role of this gene in pathogenicity of M. globosa, we applied Real-time PCR to investigate the differentially expressed of the MGL_3741 gene in healthy and pathogenic states. Our results indicate a significant difference between two mentioned stats. These results revealed that ILV3-like gene in M. globosa can be related to the pathogenicity of this yeast.

langue originaleAnglais
Pages (de - à)938-944
Nombre de pages7
journalMycoses
Volume61
Numéro de publication12
Les DOIs
étatPublié - 1 déc. 2018
Modification externeOui

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