Microbiota modulation of myeloid cells in cancer therapy

Romina S. Goldszmid, Amiran Dzutsev, Sophie Viaud, Laurence Zitvogel, Nicholas P. Restifo, Giorgio Trinchieri

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    34 Citations (Scopus)

    Résumé

    Myeloid cells represent a major component of the tumor microenvironment, where they play divergent dual roles. They can induce antitumor immune responses, but mostly they promote immune evasion, tumor progression, and metastasis formation. Thus, strategies aiming at reprogramming the tumor microenvironment represent a promising immunotherapy approach. Myeloid cells respond to environmental factors including signals derived from commensal microbes. In this Cancer Immunology at the Crossroads overview, we discuss recent advances on the effects of the commensal microbiota on myeloid-cell functions and how they affect the response to cancer therapy.

    langue originaleAnglais
    Pages (de - à)103-109
    Nombre de pages7
    journalCancer Immunology Research
    Volume3
    Numéro de publication2
    Les DOIs
    étatPublié - 1 févr. 2015

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