Microdosimetric Realistic Model of a Cell with Endoplasmic Reticulum

A. De Angelis, A. Denzi, C. Merla, F. M. Andre, T. Garcia-Sanchez, L. M. Mir, F. Apollonio, M. Liberti

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    Résumé

    When investigating the biophysical effects induced by the interaction between electromagnetic fields and biological cells, it is crucial to estimate the electromagnetic field intensity at the microscopic scale (microdosimetry). This information allows to find a connection between the external applied field and the observed biological event required to establish related biomedical applications. Here, authors present a microdosimetric study based on a 2D realistic model of a cell and its endoplasmic reticulum. The microdosimetric analysis of the cell and endoplasmic reticulum was quantified in terms of electric field and transmembrane potential induced by an externally applied high amplitude 10-ns pulsed electric field. In addition, electroporated local membrane sites and pore densities were also evaluated. This study opens the way to numerically assist experimental applications of nanosecond pulsed electric fields for controlled bio-manipulation of cells and subcellular organelles.

    langue originaleAnglais
    titre2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
    EditeurInstitute of Electrical and Electronics Engineers Inc.
    Pages134-137
    Nombre de pages4
    ISBN (Electronique)9781538613115
    Les DOIs
    étatPublié - 1 juil. 2019
    Evénement41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 - Berlin, Allemagne
    Durée: 23 juil. 201927 juil. 2019

    Série de publications

    NomProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
    ISSN (imprimé)1557-170X

    Une conférence

    Une conférence41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
    Pays/TerritoireAllemagne
    La villeBerlin
    période23/07/1927/07/19

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