TY - JOUR
T1 - MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer
T2 - A Review
AU - Volovat, Simona Ruxandra
AU - Volovat, Constantin
AU - Hordila, Irina
AU - Hordila, Dorin Alexandru
AU - Mirestean, Ciprian Camil
AU - Miron, Oana Tatiana
AU - Lungulescu, Cristian
AU - Scripcariu, Dragos Viorel
AU - Stolniceanu, Cati Raluca
AU - Konsoulova-Kirova, Assia Adrianova
AU - Grigorescu, Cristina
AU - Stefanescu, Cipriana
AU - Volovat, Cristian Constantin
AU - Augustin, Iolanda
N1 - Publisher Copyright:
© Copyright © 2020 Volovat, Volovat, Hordila, Hordila, Mirestean, Miron, Lungulescu, Scripcariu, Stolniceanu, Konsoulova-Kirova, Grigorescu, Stefanescu, Volovat and Augustin.
PY - 2020/11/20
Y1 - 2020/11/20
N2 - Noncoding RNAs (ncRNAs) include a diverse range of RNA species, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). MiRNAs, ncRNAs of approximately 19–25 nucleotides in length, are involved in gene expression regulation either via degradation or silencing of the messenger RNAs (mRNAs) and have roles in multiple biological processes, including cell proliferation, differentiation, migration, angiogenesis, and apoptosis. LncRNAs, which are longer than 200 nucleotides, comprise one of the largest and most heterogeneous RNA families. LncRNAs can activate or repress gene expression through various mechanisms, acting alone or in combination with miRNAs and other molecules as part of various pathways. Until recently, most research has focused on individual lncRNA and miRNA functions as regulators, and there is limited available data on ncRNA interactions relating to the tumor growth, metastasis, and therapy of cancer, acting either on mRNA alone or as competing endogenous RNA (ceRNA) networks. Triple-negative breast cancer (TNBC) represents approximately 10%–20% of all breast cancers (BCs) and is highly heterogenous and more aggressive than other types of BC, for which current targeted treatment options include hormonotherapy, PARP inhibitors, and immunotherapy; however, no targeted therapies for TNBC are available, partly because of a lack of predictive biomarkers. With advances in proteomics, new evidence has emerged demonstrating the implications of dysregulation of ncRNAs in TNBC etiology. Here, we review the roles of lncRNAs and miRNAs implicated in TNBC, including their interactions and regulatory networks. Our synthesis provides insight into the mechanisms involved in TNBC progression and has potential to aid the discovery of new diagnostic and therapeutic strategies.
AB - Noncoding RNAs (ncRNAs) include a diverse range of RNA species, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). MiRNAs, ncRNAs of approximately 19–25 nucleotides in length, are involved in gene expression regulation either via degradation or silencing of the messenger RNAs (mRNAs) and have roles in multiple biological processes, including cell proliferation, differentiation, migration, angiogenesis, and apoptosis. LncRNAs, which are longer than 200 nucleotides, comprise one of the largest and most heterogeneous RNA families. LncRNAs can activate or repress gene expression through various mechanisms, acting alone or in combination with miRNAs and other molecules as part of various pathways. Until recently, most research has focused on individual lncRNA and miRNA functions as regulators, and there is limited available data on ncRNA interactions relating to the tumor growth, metastasis, and therapy of cancer, acting either on mRNA alone or as competing endogenous RNA (ceRNA) networks. Triple-negative breast cancer (TNBC) represents approximately 10%–20% of all breast cancers (BCs) and is highly heterogenous and more aggressive than other types of BC, for which current targeted treatment options include hormonotherapy, PARP inhibitors, and immunotherapy; however, no targeted therapies for TNBC are available, partly because of a lack of predictive biomarkers. With advances in proteomics, new evidence has emerged demonstrating the implications of dysregulation of ncRNAs in TNBC etiology. Here, we review the roles of lncRNAs and miRNAs implicated in TNBC, including their interactions and regulatory networks. Our synthesis provides insight into the mechanisms involved in TNBC progression and has potential to aid the discovery of new diagnostic and therapeutic strategies.
KW - biomarkers
KW - ceRNA
KW - circulating miRNA
KW - LncRNA
KW - miRNA
KW - triple negative breast cancer
UR - http://www.scopus.com/inward/record.url?scp=85097251033&partnerID=8YFLogxK
U2 - 10.3389/fonc.2020.526850
DO - 10.3389/fonc.2020.526850
M3 - Review article
AN - SCOPUS:85097251033
SN - 2234-943X
VL - 10
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 526850
ER -