MLL-AF1q fusion resulting from t(1;11) in acute leukemia

M. Busson-Le Coniat; F. Salomon-Nguyen; J. Hillion; O. A. Bernard; R. Berger

doi:10.1038/sj.leu.2401299

MLL-AF1q fusion resulting from t(1;11) in acute leukemia

M. Busson-Le Coniat, F. Salomon-Nguyen, J. Hillion, O. A. Bernard, R. Berger

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Résumé

The MLL gene, located on chromosome band 11q23 is fused to different partner genes as a result of various chromosomal translocations in hematopoietic malignancies. A t(1;11) (q21;q23) resulting in a MLL-AF1q fusion gene has previously been reported. Cytogenetic studies on six cases are reported, including one three-way translocation. FISH analysis using a YAC encompassing the MLL gene and a YAC encompassing the AF1q locus showed splitting in three cases and two patients, respectively. PCR analysis of two cases confirmed that AF1q is specifically associated with t(1;11)(q21;q23). The MLL-AF1q fusion mRNA was similar to that previously described in one case and involved MLL exon 7 in the other. This study confirms the specific involvement of AF1q in t(1;11) (q21;q23)-positive acute leukemia with monocytic involvement.

langue originale	Anglais
Pages (de - à)	302-306
Nombre de pages	5
journal	Leukemia
Volume	13
Numéro de publication	2
Les DOIs	https://doi.org/10.1038/sj.leu.2401299
état	Publié - 1 janv. 1999
Modification externe	Oui

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10.1038/sj.leu.2401299

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@article{9f71a79edf3e43369c59cf2d7f64b185,

title = "MLL-AF1q fusion resulting from t(1;11) in acute leukemia",

abstract = "The MLL gene, located on chromosome band 11q23 is fused to different partner genes as a result of various chromosomal translocations in hematopoietic malignancies. A t(1;11) (q21;q23) resulting in a MLL-AF1q fusion gene has previously been reported. Cytogenetic studies on six cases are reported, including one three-way translocation. FISH analysis using a YAC encompassing the MLL gene and a YAC encompassing the AF1q locus showed splitting in three cases and two patients, respectively. PCR analysis of two cases confirmed that AF1q is specifically associated with t(1;11)(q21;q23). The MLL-AF1q fusion mRNA was similar to that previously described in one case and involved MLL exon 7 in the other. This study confirms the specific involvement of AF1q in t(1;11) (q21;q23)-positive acute leukemia with monocytic involvement.",

keywords = "Acute myelomonocytic leukemia, FISH, MLL-AF1q, T(1:11), Translocation",

author = "{Busson-Le Coniat}, M. and F. Salomon-Nguyen and J. Hillion and Bernard, {O. A.} and R. Berger",

note = "Funding Information: This work was supported in part by grants from The Ligue Nationale Contre Le Cancer (Comit{\'e} National et Comit{\'e} de Paris), and the Fondation Saint-Louis. FS-N is a recipient of a fellowship from the The Ligue Nationale Contre Le Cancer.",

year = "1999",

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doi = "10.1038/sj.leu.2401299",

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AU - Busson-Le Coniat, M.

AU - Salomon-Nguyen, F.

AU - Hillion, J.

AU - Bernard, O. A.

AU - Berger, R.

N1 - Funding Information: This work was supported in part by grants from The Ligue Nationale Contre Le Cancer (Comité National et Comité de Paris), and the Fondation Saint-Louis. FS-N is a recipient of a fellowship from the The Ligue Nationale Contre Le Cancer.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - The MLL gene, located on chromosome band 11q23 is fused to different partner genes as a result of various chromosomal translocations in hematopoietic malignancies. A t(1;11) (q21;q23) resulting in a MLL-AF1q fusion gene has previously been reported. Cytogenetic studies on six cases are reported, including one three-way translocation. FISH analysis using a YAC encompassing the MLL gene and a YAC encompassing the AF1q locus showed splitting in three cases and two patients, respectively. PCR analysis of two cases confirmed that AF1q is specifically associated with t(1;11)(q21;q23). The MLL-AF1q fusion mRNA was similar to that previously described in one case and involved MLL exon 7 in the other. This study confirms the specific involvement of AF1q in t(1;11) (q21;q23)-positive acute leukemia with monocytic involvement.

AB - The MLL gene, located on chromosome band 11q23 is fused to different partner genes as a result of various chromosomal translocations in hematopoietic malignancies. A t(1;11) (q21;q23) resulting in a MLL-AF1q fusion gene has previously been reported. Cytogenetic studies on six cases are reported, including one three-way translocation. FISH analysis using a YAC encompassing the MLL gene and a YAC encompassing the AF1q locus showed splitting in three cases and two patients, respectively. PCR analysis of two cases confirmed that AF1q is specifically associated with t(1;11)(q21;q23). The MLL-AF1q fusion mRNA was similar to that previously described in one case and involved MLL exon 7 in the other. This study confirms the specific involvement of AF1q in t(1;11) (q21;q23)-positive acute leukemia with monocytic involvement.

KW - Acute myelomonocytic leukemia

KW - FISH

KW - MLL-AF1q

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KW - Translocation

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