TY - JOUR
T1 - MnAl-Layered Double Hydroxide Nanosheets Infused with Fluorouracil for Cancer Diagnosis and Therapy
AU - Dragoi, Brindusa
AU - Uritu, Cristina Mariana
AU - Agrigoroaie, Laurentiu
AU - Lutic, Doina
AU - Hulea, Vasile
AU - Postole, Georgeta
AU - Coroaba, Adina
AU - Carasevici, Eugen
N1 - Publisher Copyright:
©
PY - 2021/2/26
Y1 - 2021/2/26
N2 - Nanotheranostic materials with a layered double hydrotalcite (LDH) structure, containing manganese as a contrast agent for MRI and fluorouracil (FU) as a model anticancer drug, were prepared. The manganese was rationally included in the two-dimensional (2D) LDH construction by co-precipitation (CP) at low suprasaturation at a theoretic Mn/Al ratio of 2. The anticancer drug was strategically introduced in the layered solid by two synthetic approaches, that is, CP at low suprasaturation and CP coupled with ion exchange (IE). The materials were extensively characterized for their composition, structure, texture, morphology, and oxidation state by AAS, XRD, N2 physisorption, FT-IR, SEM, TEM, TGA, DR UV-vis, and XPS. The results of physicochemical characterization revealed high-quality 2D materials in which manganese mainly exists as Mn2+ and Mn3+ while the mass loading of FU was 6.96 and 5.28% for the samples prepared by CP and CP coupled with IE, respectively. The nanomaterials exhibited high r1 and r2 relaxivities, particularly at pH = 7.4. The mathematical models used to fit the experimental data revealed a quasi-Fickian diffusion of the FU release from MnAl-LDH.
AB - Nanotheranostic materials with a layered double hydrotalcite (LDH) structure, containing manganese as a contrast agent for MRI and fluorouracil (FU) as a model anticancer drug, were prepared. The manganese was rationally included in the two-dimensional (2D) LDH construction by co-precipitation (CP) at low suprasaturation at a theoretic Mn/Al ratio of 2. The anticancer drug was strategically introduced in the layered solid by two synthetic approaches, that is, CP at low suprasaturation and CP coupled with ion exchange (IE). The materials were extensively characterized for their composition, structure, texture, morphology, and oxidation state by AAS, XRD, N2 physisorption, FT-IR, SEM, TEM, TGA, DR UV-vis, and XPS. The results of physicochemical characterization revealed high-quality 2D materials in which manganese mainly exists as Mn2+ and Mn3+ while the mass loading of FU was 6.96 and 5.28% for the samples prepared by CP and CP coupled with IE, respectively. The nanomaterials exhibited high r1 and r2 relaxivities, particularly at pH = 7.4. The mathematical models used to fit the experimental data revealed a quasi-Fickian diffusion of the FU release from MnAl-LDH.
KW - contrast agent
KW - fluorouracil
KW - LDH
KW - manganese
KW - theranostic
UR - http://www.scopus.com/inward/record.url?scp=85100005561&partnerID=8YFLogxK
U2 - 10.1021/acsanm.0c03365
DO - 10.1021/acsanm.0c03365
M3 - Article
AN - SCOPUS:85100005561
SN - 2574-0970
VL - 4
SP - 2061
EP - 2075
JO - ACS Applied Nano Materials
JF - ACS Applied Nano Materials
IS - 2
ER -