Modèles alternatifs (5) Crassostrea gigas, une huître au service de la recherche sur le cancer

Charlotte Corporeau; Arnaud Huvet; Vianney Pichereau; Lizenn Delisle; Claudie Quéré; Christine Dubreuil; Sébastien Artigaud; Catherine Brenner; Monique Meyenberg Cunha-De Padua; Nathalie Mazure

doi:10.1051/medsci/2019079

Modèles alternatifs (5) Crassostrea gigas, une huître au service de la recherche sur le cancer

Charlotte Corporeau, Arnaud Huvet, Vianney Pichereau, Lizenn Delisle, Claudie Quéré, Christine Dubreuil, Sébastien Artigaud, Catherine Brenner, Monique Meyenberg Cunha-De Padua, Nathalie Mazure

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

3 Citations (Scopus)

Résumé

The Warburg effect is one of the hallmarks of cancer cells in humans. It is a true metabolic reprogramming to aerobic glycolysis, allowing cancer cells to meet their particular energy needs for growth, proliferation, and resistance to apoptosis, depending on the microenvironment they encounter within the tumor. We have recently discovered that the Crassostrea gigas oyster can naturally reprogram its metabolism to the Warburg effect. Thus, the oyster becomes a new invertebrate model useful for cancer research. Due to its lifestyle, the oyster C. gigas has special abilities to adapt its metabolism to the extreme changes in the environment in which it is located. The oyster C. gigas is therefore a model of interest to study how the environment can control the Warburg effect under conditions that could not be explored in vertebrate model species.

Titre traduit de la contribution	The oyster Crassostrea gigas, a new model against cancer
langue originale	Français
Pages (de - à)	463-466
Nombre de pages	4
journal	Medecine/Sciences
Volume	35
Numéro de publication	5
Les DOIs	https://doi.org/10.1051/medsci/2019079
état	Publié - 1 janv. 2019

Accès au document

10.1051/medsci/2019079

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Contient cette citation

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title = "Mod{\`e}les alternatifs (5) Crassostrea gigas, une hu{\^i}tre au service de la recherche sur le cancer",

abstract = "The Warburg effect is one of the hallmarks of cancer cells in humans. It is a true metabolic reprogramming to aerobic glycolysis, allowing cancer cells to meet their particular energy needs for growth, proliferation, and resistance to apoptosis, depending on the microenvironment they encounter within the tumor. We have recently discovered that the Crassostrea gigas oyster can naturally reprogram its metabolism to the Warburg effect. Thus, the oyster becomes a new invertebrate model useful for cancer research. Due to its lifestyle, the oyster C. gigas has special abilities to adapt its metabolism to the extreme changes in the environment in which it is located. The oyster C. gigas is therefore a model of interest to study how the environment can control the Warburg effect under conditions that could not be explored in vertebrate model species.",

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AU - Corporeau, Charlotte

AU - Huvet, Arnaud

AU - Pichereau, Vianney

AU - Delisle, Lizenn

AU - Quéré, Claudie

AU - Dubreuil, Christine

AU - Artigaud, Sébastien

AU - Brenner, Catherine

AU - Cunha-De Padua, Monique Meyenberg

AU - Mazure, Nathalie

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AB - The Warburg effect is one of the hallmarks of cancer cells in humans. It is a true metabolic reprogramming to aerobic glycolysis, allowing cancer cells to meet their particular energy needs for growth, proliferation, and resistance to apoptosis, depending on the microenvironment they encounter within the tumor. We have recently discovered that the Crassostrea gigas oyster can naturally reprogram its metabolism to the Warburg effect. Thus, the oyster becomes a new invertebrate model useful for cancer research. Due to its lifestyle, the oyster C. gigas has special abilities to adapt its metabolism to the extreme changes in the environment in which it is located. The oyster C. gigas is therefore a model of interest to study how the environment can control the Warburg effect under conditions that could not be explored in vertebrate model species.

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