Modeling the Interaction between the Microenvironment and Tumor Cells in Brain Tumors

Claudia Pasqualini, Tatsuya Kozaki, Marco Bruschi, Thi Hai Hoa Nguyen, Véronique Minard-Colin, David Castel, Jacques Grill, Florent Ginhoux

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    33 Citations (Scopus)

    Résumé

    Despite considerable recent advances in understanding and treating many other cancers, malignant brain tumors remain associated with low survival or severe long-term sequelae. Limited progress, including development of immunotherapies, relates in part to difficulties in accurately reproducing brain microenvironment with current preclinical models. The cellular interactions among resident microglia, recruited tumor-associated macrophages, stromal cells, glial cells, neurons, and cancer cells and how they affect tumor growth or behavior are emerging, yet many questions remain. The role of the blood-brain barrier, extracellular matrix components, and heterogeneity among tumor types and within different regions of a single tumor further complicate the matter. Here, we focus on brain microenvironment features impacted by tumor biology. We also discuss limits of current preclinical models and how complementary models, such as humanized animals and organoids, will allow deeper mechanistic insights on cancer biology, allowing for more efficient testing of therapeutic strategies, including immunotherapy, for brain cancers.

    langue originaleAnglais
    Pages (de - à)1025-1044
    Nombre de pages20
    journalNeuron
    Volume108
    Numéro de publication6
    Les DOIs
    étatPublié - 23 déc. 2020

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