Molecular analysis of chromosomal breakpoints in three examples of chromosomal translocation involving the TEL gene

S. P. Romana; H. Poirel; V. Della Valle; M. Mauchauffe; M. Busson-Le Coniat; R. Berger; O. A. Bernard

doi:10.1038/sj.leu.2401564

Molecular analysis of chromosomal breakpoints in three examples of chromosomal translocation involving the TEL gene

S. P. Romana, H. Poirel, V. Della Valle, M. Mauchauffe, M. Busson-Le Coniat, R. Berger, O. A. Bernard

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Résumé

The TEL gene is involved in several chromosomal abnormalities of human hematopoietic malignancies. The chromosome 12 breakpoints frequently lie within the fifth intron of the gene, particularly in the most frequent translocation involving TEL, the t(12;21)(p13;q22). In order to search for a peculiar mechanism involved in the genesis of these translocations, we have established the sequence of two t(12;21) and a t(9;12)(q24;p13) breakpoints. Our data do not reveal the involvement of VDJ recombinase activity or Alu sequences but favor the occurrence of staggered breaks and DNA repair activity in the genesis of these translocations.

langue originale	Anglais
Pages (de - à)	1754-1759
Nombre de pages	6
journal	Leukemia
Volume	13
Numéro de publication	11
Les DOIs	https://doi.org/10.1038/sj.leu.2401564
état	Publié - 1 janv. 1999
Modification externe	Oui

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10.1038/sj.leu.2401564

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@article{9c2485862ec9492e90dba989500fb165,

title = "Molecular analysis of chromosomal breakpoints in three examples of chromosomal translocation involving the TEL gene",

abstract = "The TEL gene is involved in several chromosomal abnormalities of human hematopoietic malignancies. The chromosome 12 breakpoints frequently lie within the fifth intron of the gene, particularly in the most frequent translocation involving TEL, the t(12;21)(p13;q22). In order to search for a peculiar mechanism involved in the genesis of these translocations, we have established the sequence of two t(12;21) and a t(9;12)(q24;p13) breakpoints. Our data do not reveal the involvement of VDJ recombinase activity or Alu sequences but favor the occurrence of staggered breaks and DNA repair activity in the genesis of these translocations.",

keywords = "Leukemia, Mechanism, TEL, Translocation",

author = "Romana, {S. P.} and H. Poirel and {Della Valle}, V. and M. Mauchauffe and {Busson-Le Coniat}, M. and R. Berger and Bernard, {O. A.}",

note = "Funding Information: This work was supported by grants from INSERM, Association pour la Recherche sur le Cancer, Ligue Nationale Contre le Cancer, Ligue D{\'e}partementale Contre le Cancer (Comit{\'e} de Paris). We thank C Berthou and M Lessard (H{\^o}pital Morvan, CHR de Brest, France) for providing us with the t(9;12) sample.",

year = "1999",

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doi = "10.1038/sj.leu.2401564",

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TY - JOUR

T1 - Molecular analysis of chromosomal breakpoints in three examples of chromosomal translocation involving the TEL gene

AU - Romana, S. P.

AU - Poirel, H.

AU - Della Valle, V.

AU - Mauchauffe, M.

AU - Busson-Le Coniat, M.

AU - Berger, R.

AU - Bernard, O. A.

N1 - Funding Information: This work was supported by grants from INSERM, Association pour la Recherche sur le Cancer, Ligue Nationale Contre le Cancer, Ligue Départementale Contre le Cancer (Comité de Paris). We thank C Berthou and M Lessard (Hôpital Morvan, CHR de Brest, France) for providing us with the t(9;12) sample.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - The TEL gene is involved in several chromosomal abnormalities of human hematopoietic malignancies. The chromosome 12 breakpoints frequently lie within the fifth intron of the gene, particularly in the most frequent translocation involving TEL, the t(12;21)(p13;q22). In order to search for a peculiar mechanism involved in the genesis of these translocations, we have established the sequence of two t(12;21) and a t(9;12)(q24;p13) breakpoints. Our data do not reveal the involvement of VDJ recombinase activity or Alu sequences but favor the occurrence of staggered breaks and DNA repair activity in the genesis of these translocations.

AB - The TEL gene is involved in several chromosomal abnormalities of human hematopoietic malignancies. The chromosome 12 breakpoints frequently lie within the fifth intron of the gene, particularly in the most frequent translocation involving TEL, the t(12;21)(p13;q22). In order to search for a peculiar mechanism involved in the genesis of these translocations, we have established the sequence of two t(12;21) and a t(9;12)(q24;p13) breakpoints. Our data do not reveal the involvement of VDJ recombinase activity or Alu sequences but favor the occurrence of staggered breaks and DNA repair activity in the genesis of these translocations.

KW - Leukemia

KW - Mechanism

KW - TEL

KW - Translocation

UR - http://www.scopus.com/inward/record.url?scp=0032740763&partnerID=8YFLogxK

U2 - 10.1038/sj.leu.2401564

DO - 10.1038/sj.leu.2401564

M3 - Article

C2 - 10557049

AN - SCOPUS:0032740763

SN - 0887-6924

VL - 13

SP - 1754

EP - 1759

JO - Leukemia

JF - Leukemia

IS - 11

ER -