Molecular basis of IIq23 rearrangements in hematopoietic malignant proliferations

Olivier A. Bernard; Roland Berger

doi:10.1002/gcc.2870130202

Molecular basis of IIq23 rearrangements in hematopoietic malignant proliferations

Olivier A. Bernard, Roland Berger

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

212 Citations (Scopus)

Résumé

Chromosomal abnormalities of the 11q23 band occur frequently in various hematopoietic malignant disorders. Because numerous partner chromosomes have been previously described, it is now important to determine the number of genes involved at 11q23 and to clarify the role of the partner genes. Recent efforts in several laboratories have identified a trithorax‐related gene that is involved in most of the 11q23 abnormalities. The aim of this review is to summarize the recent data concerning these 11q23 rearrangements and the understanding of their consequences.

langue originale	Anglais
Pages (de - à)	75-85
Nombre de pages	11
journal	Genes Chromosomes and Cancer
Volume	13
Numéro de publication	2
Les DOIs	https://doi.org/10.1002/gcc.2870130202
état	Publié - 1 janv. 1995

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10.1002/gcc.2870130202

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title = "Molecular basis of IIq23 rearrangements in hematopoietic malignant proliferations",

abstract = "Chromosomal abnormalities of the 11q23 band occur frequently in various hematopoietic malignant disorders. Because numerous partner chromosomes have been previously described, it is now important to determine the number of genes involved at 11q23 and to clarify the role of the partner genes. Recent efforts in several laboratories have identified a trithorax‐related gene that is involved in most of the 11q23 abnormalities. The aim of this review is to summarize the recent data concerning these 11q23 rearrangements and the understanding of their consequences.",

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AU - Berger, Roland

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N2 - Chromosomal abnormalities of the 11q23 band occur frequently in various hematopoietic malignant disorders. Because numerous partner chromosomes have been previously described, it is now important to determine the number of genes involved at 11q23 and to clarify the role of the partner genes. Recent efforts in several laboratories have identified a trithorax‐related gene that is involved in most of the 11q23 abnormalities. The aim of this review is to summarize the recent data concerning these 11q23 rearrangements and the understanding of their consequences.

AB - Chromosomal abnormalities of the 11q23 band occur frequently in various hematopoietic malignant disorders. Because numerous partner chromosomes have been previously described, it is now important to determine the number of genes involved at 11q23 and to clarify the role of the partner genes. Recent efforts in several laboratories have identified a trithorax‐related gene that is involved in most of the 11q23 abnormalities. The aim of this review is to summarize the recent data concerning these 11q23 rearrangements and the understanding of their consequences.

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