TY - JOUR
T1 - Molecular mechanisms of necroptosis
T2 - An ordered cellular explosion
AU - Vandenabeele, Peter
AU - Galluzzi, Lorenzo
AU - Vanden Berghe, Tom
AU - Kroemer, Guido
N1 - Funding Information:
We apologize to our colleagues for not citing all primary research papers owing to space restrictions, and we thank W. Declercq for fruitful discussions. Electron microscopy pictures in Box 1 were kindly provided by D. Krysko, Ghent University, VIB, Belgium. P.V. holds a Methusalem grant from the Flemish Government (BOF09/01M00709) and is supported by the Flanders Institute for Biotechnology (VIB), the Interuniversity Poles of Attraction-Belgian Science Policy (IAP6/18), Fonds voor Wetenschappelijk Onderzoek – Vlaanderen (FWO, G.0133.05 and 3G.0218.06), The Special Research Fund of Ghent University (Geconcerteerde Onderzoekstacties 12.0505.02) and the European Commission (EU Marie Curie Training and Mobility Program, ApopTrain, MRTN-CT-035,624; EU FP7 Integrated Project, APO-SYS, HEALTH-F4-2007-200,767; EU FP6 Integrated Project, Epistem, LSHB-CT-2005-019,067; Marie Curie Training and Mobility Program). L.G. and T.V.B. are financed by APO-SYS and FWO, respectively. G.K. is supported by Ligue Nationale contre le Cancer (Equipe labellisée), Agence Nationale pour la Recherche (ANR), the European Commission (APO-SYS, ChemoRes, ApopTrain, Active p53), Fondation pour la Recherche Médicale (FRM), Institut National du Cancer (INCa) and Cancéropôle Ile-de-France.
PY - 2010/10/1
Y1 - 2010/10/1
N2 - For a long time, apoptosis was considered the sole form of programmed cell death during development, homeostasis and disease, whereas necrosis was regarded as an unregulated and uncontrollable process. Evidence now reveals that necrosis can also occur in a regulated manner. The initiation of programmed necrosis, 'necroptosis', by death receptors (such as tumour necrosis factor receptor 1) requires the kinase activity of receptor-interacting protein 1 (RIP1; also known as RIPK1) and RIP3 (also known as RIPK3), and its execution involves the active disintegration of mitochondrial, lysosomal and plasma membranes. Necroptosis participates in the pathogenesis of diseases, including ischaemic injury, neurodegeneration and viral infection, thereby representing an attractive target for the avoidance of unwarranted cell death.
AB - For a long time, apoptosis was considered the sole form of programmed cell death during development, homeostasis and disease, whereas necrosis was regarded as an unregulated and uncontrollable process. Evidence now reveals that necrosis can also occur in a regulated manner. The initiation of programmed necrosis, 'necroptosis', by death receptors (such as tumour necrosis factor receptor 1) requires the kinase activity of receptor-interacting protein 1 (RIP1; also known as RIPK1) and RIP3 (also known as RIPK3), and its execution involves the active disintegration of mitochondrial, lysosomal and plasma membranes. Necroptosis participates in the pathogenesis of diseases, including ischaemic injury, neurodegeneration and viral infection, thereby representing an attractive target for the avoidance of unwarranted cell death.
UR - http://www.scopus.com/inward/record.url?scp=77957105977&partnerID=8YFLogxK
U2 - 10.1038/nrm2970
DO - 10.1038/nrm2970
M3 - Review article
C2 - 20823910
AN - SCOPUS:77957105977
SN - 1471-0072
VL - 11
SP - 700
EP - 714
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 10
ER -