MOZ/TIF2-induced acute myeloid leukaemia in transgenic fish

Julia Zhuravleva, Jérôme Paggetti, Laurent Martin, Arlette Hammann, Eric Solary, Jean Noël Bastie, Laurent Delva

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

67 Citations (Scopus)

Résumé

The inv(8)(p11q13) chromosomal abnormality, described in acute myeloid leukaemias (AML), fuses the histone acetyl-transferase (HAT) MYST3 (MOZ) gene with another HAT gene, NCOA2 (TIF2). We generated a transgenic zebrafish in which the MYST3//NCOA2 fusion gene was expressed under control of the spi1 promoter. An AML developed in 2 of 180 MYST3/NCOA2-EGFP-expressing embryos, 14 and 26 months after injection of the fusion gene in a one-cell embryo, respectively. This leukaemia was characterised by an extensive invasion of kidneys by myeloid blast cells. This model, which is the first zebrafish model of AML, demonstrates the oncogenic potency of MYST3/NCOA2 fusion gene.

langue originaleAnglais
Pages (de - à)378-382
Nombre de pages5
journalBritish Journal of Haematology
Volume143
Numéro de publication3
Les DOIs
étatPublié - 1 nov. 2008
Modification externeOui

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