mRNA translation from an antigen presentation perspective: A tribute to the works of Nilabh Shastri

Sebastien Apcher, Maria Tovar-Fernadez, Sarah Ducellier, Aikaterini Thermou, Megane Nascimento, Ewa Sroka, Robin Fahraeus

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    3 Citations (Scopus)

    Résumé

    The field of mRNA translation has witnessed an impressive expansion in the last decade. The once standard model of translation initiation has undergone, and is still undergoing, a major overhaul, partly due to more recent technical advancements detailing, for example, initiation at non-AUG codons. However, some of the pioneering works in this area have come from immunology and more precisely from the field of antigen presentation to the major histocompatibility class I (MHC-I) pathway. Despite early innovative studies from the lab of Nilabh Shastri demonstrating alternative mRNA translation initiation as a source for MHC-I peptide substrates, the mRNA translation field did not include these into their models. It was not until the introduction of the ribo-sequence technique that the extent of non-canonical translation initiation became widely acknowledged. The detection of peptides on MHC-I molecules by CD8 + T cells is extremely sensitive, making this a superior model system for studying alternative mRNA translation initiation from specific mRNAs. In view of this, we give a brief history on alternative initiation from an immunology perspective and its fundamental role in allowing the immune system to distinguish self from non-self and at the same time pay tribute to the works of Nilabh Shastri.

    langue originaleAnglais
    Pages (de - à)305-308
    Nombre de pages4
    journalMolecular Immunology
    Volume141
    Les DOIs
    étatPublié - 1 janv. 2022

    Contient cette citation