TY - JOUR
T1 - mRNA translation from an antigen presentation perspective
T2 - A tribute to the works of Nilabh Shastri
AU - Apcher, Sebastien
AU - Tovar-Fernadez, Maria
AU - Ducellier, Sarah
AU - Thermou, Aikaterini
AU - Nascimento, Megane
AU - Sroka, Ewa
AU - Fahraeus, Robin
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2022/1/1
Y1 - 2022/1/1
N2 - The field of mRNA translation has witnessed an impressive expansion in the last decade. The once standard model of translation initiation has undergone, and is still undergoing, a major overhaul, partly due to more recent technical advancements detailing, for example, initiation at non-AUG codons. However, some of the pioneering works in this area have come from immunology and more precisely from the field of antigen presentation to the major histocompatibility class I (MHC-I) pathway. Despite early innovative studies from the lab of Nilabh Shastri demonstrating alternative mRNA translation initiation as a source for MHC-I peptide substrates, the mRNA translation field did not include these into their models. It was not until the introduction of the ribo-sequence technique that the extent of non-canonical translation initiation became widely acknowledged. The detection of peptides on MHC-I molecules by CD8 + T cells is extremely sensitive, making this a superior model system for studying alternative mRNA translation initiation from specific mRNAs. In view of this, we give a brief history on alternative initiation from an immunology perspective and its fundamental role in allowing the immune system to distinguish self from non-self and at the same time pay tribute to the works of Nilabh Shastri.
AB - The field of mRNA translation has witnessed an impressive expansion in the last decade. The once standard model of translation initiation has undergone, and is still undergoing, a major overhaul, partly due to more recent technical advancements detailing, for example, initiation at non-AUG codons. However, some of the pioneering works in this area have come from immunology and more precisely from the field of antigen presentation to the major histocompatibility class I (MHC-I) pathway. Despite early innovative studies from the lab of Nilabh Shastri demonstrating alternative mRNA translation initiation as a source for MHC-I peptide substrates, the mRNA translation field did not include these into their models. It was not until the introduction of the ribo-sequence technique that the extent of non-canonical translation initiation became widely acknowledged. The detection of peptides on MHC-I molecules by CD8 + T cells is extremely sensitive, making this a superior model system for studying alternative mRNA translation initiation from specific mRNAs. In view of this, we give a brief history on alternative initiation from an immunology perspective and its fundamental role in allowing the immune system to distinguish self from non-self and at the same time pay tribute to the works of Nilabh Shastri.
KW - Antigen presentation
KW - MHC class I pathway
KW - mRNA translation initiation
UR - http://www.scopus.com/inward/record.url?scp=85121128758&partnerID=8YFLogxK
U2 - 10.1016/j.molimm.2021.12.010
DO - 10.1016/j.molimm.2021.12.010
M3 - Review article
C2 - 34920325
AN - SCOPUS:85121128758
SN - 0161-5890
VL - 141
SP - 305
EP - 308
JO - Molecular Immunology
JF - Molecular Immunology
ER -