TY - JOUR
T1 - Mucoepidermoid carcinoma of salivary glands
T2 - A French Network of Rare Head and Neck Tumors (REFCOR) prospective study of 292 cases
AU - REFCOR members
AU - Dahan, Laurie Saloner
AU - Giorgi, Roch
AU - Vergez, Sébastien
AU - Le Taillandier de Gabory, Ludovic
AU - Costes-Martineau, Valérie
AU - Herman, Philippe
AU - Poissonnet, Gilles
AU - Mauvais, Olivier
AU - Malard, Olivier
AU - Garrel, Renaud
AU - Uro-Coste, Emmanuelle
AU - Barry, Béatrix
AU - Bach, Christine
AU - Chevalier, Dominique
AU - Mouawad, Francois
AU - Merol, Jean Claude
AU - Bastit, Vianney
AU - Thariat, Juliette
AU - Gilain, Laurent
AU - Dufour, Xavier
AU - Righini, Christian Adrien
AU - Moya-Plana, Antoine
AU - Even, Caroline
AU - Radulesco, Thomas
AU - Michel, Justin
AU - Baujat, Bertrand
AU - Fakhry, Nicolas
AU - Albert, S.
AU - Andry, G.
AU - Babin, E.
AU - Bach, C.
AU - Badet, J. M.
AU - Badoual, C.
AU - Baglin, A. C.
AU - Banal, A.
AU - Barry, B.
AU - Baudin, E.
AU - Baujat, B.
AU - Bensadoun, R. J.
AU - Bertolus, C.
AU - Bessède, J. P.
AU - Blanchard, D.
AU - Borel, C.
AU - Bozorg-Grayeli, A.
AU - Breheret, R.
AU - Breton, P.
AU - Brugel, L.
AU - Calais, G.
AU - Casiraghi, O.
AU - Cassagnau, E.
N1 - Publisher Copyright:
© 2020 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Background: To describe the characteristics of the largest European study of MEC of salivary glands and to determine the prognostic factors for overall and disease free survival. Patients and methods: Patients with MEC were prospectively included in the Réseau d'Expertise Français sur les Cancers ORL Rares (REFCOR, French Network of Rare Head and Neck Tumors) database between 2009 and 2015. Results: A total of 292 patients were included. Tumors were classified as low grade in 175 cases (60%), intermediate in 39 (13%) and high grade in 78 (27%). Median follow-up was 26 months. The 5-year OS and DFS rates were respectively 83% and 69%. In multivariate analysis, age (p = 0.004), diabetes (p = 0.02) and advanced stage (p = 0.03) were found to have a significant negative impact on OS. Diabetes (p = 0.001), alcohol consumption (p = 0.003) and advanced stage (p = 0.001) were found to have a significant negative impact on DFS. Compare to low grade, high grade tended to have a negative impact on OS (p = 0.05) and had a significant effect on DFS (0.002) while intermediate grade had no significant influence on survival. The surgical treatment had a positive impact on both OS (p = 0.00005) and DFS (p = 0.0005). Postoperative radiotherapy had no impact in multivariate analysis. Conclusion: Advanced clinical stage, high grade tumor, high age, the impossibility of carrying out a complete surgical resection, and diabetes are the main prognostic factors in this prospective series of patients with MEC. Such findings open new research perspectives on the influence of these components on initial patient care.
AB - Background: To describe the characteristics of the largest European study of MEC of salivary glands and to determine the prognostic factors for overall and disease free survival. Patients and methods: Patients with MEC were prospectively included in the Réseau d'Expertise Français sur les Cancers ORL Rares (REFCOR, French Network of Rare Head and Neck Tumors) database between 2009 and 2015. Results: A total of 292 patients were included. Tumors were classified as low grade in 175 cases (60%), intermediate in 39 (13%) and high grade in 78 (27%). Median follow-up was 26 months. The 5-year OS and DFS rates were respectively 83% and 69%. In multivariate analysis, age (p = 0.004), diabetes (p = 0.02) and advanced stage (p = 0.03) were found to have a significant negative impact on OS. Diabetes (p = 0.001), alcohol consumption (p = 0.003) and advanced stage (p = 0.001) were found to have a significant negative impact on DFS. Compare to low grade, high grade tended to have a negative impact on OS (p = 0.05) and had a significant effect on DFS (0.002) while intermediate grade had no significant influence on survival. The surgical treatment had a positive impact on both OS (p = 0.00005) and DFS (p = 0.0005). Postoperative radiotherapy had no impact in multivariate analysis. Conclusion: Advanced clinical stage, high grade tumor, high age, the impossibility of carrying out a complete surgical resection, and diabetes are the main prognostic factors in this prospective series of patients with MEC. Such findings open new research perspectives on the influence of these components on initial patient care.
KW - Cancer
KW - Mucoepidermoid carcinoma
KW - Parotid gland
KW - Salivary glands
UR - http://www.scopus.com/inward/record.url?scp=85096863210&partnerID=8YFLogxK
U2 - 10.1016/j.ejso.2020.11.123
DO - 10.1016/j.ejso.2020.11.123
M3 - Article
C2 - 33248902
AN - SCOPUS:85096863210
SN - 0748-7983
VL - 47
SP - 1376
EP - 1383
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
IS - 6
ER -