Multicenter assessment of exclusive endoscopic endonasal approach for the treatment of 53 olfactory neuroblastomas

Ludovic de Gabory; Benjamin Verillaud; Cécile Rumeau; Philippe Herman; Roger Jankowski; Justin Michel; Héloïse de Kermadec; André Coste; Geoffrey Mortuaire; Christian Righini; Emile Reyt; Olivier Choussy; Vincent Trévillot; Louis Crampette; Elie Serrano; Anjarasoa Tsaranazy; Pierre Louis Bastier; Sebastien Vergez

doi:10.1002/hed.25064

Multicenter assessment of exclusive endoscopic endonasal approach for the treatment of 53 olfactory neuroblastomas

Ludovic de Gabory, Benjamin Verillaud, Cécile Rumeau, Philippe Herman, Roger Jankowski, Justin Michel, Héloïse de Kermadec, André Coste, Geoffrey Mortuaire, Christian Righini, Emile Reyt, Olivier Choussy, Vincent Trévillot, Louis Crampette, Elie Serrano, Anjarasoa Tsaranazy, Pierre Louis Bastier, Sebastien Vergez

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Résumé

Background: Given the particularities of olfactory neuroblastoma (ONB) and the lack of studies on the subject, a multicenter collaborative study was conducted to assess treatment strategy. Methods: Fifty-three patients with ONB were included from the French Rare Head and Neck Cancer Expert Network (REFCOR) database: 16T1, 8T2, 19T3, and 10T4. All cases were treated endoscopically with skull base removal and repair in 26 cases (49%) and without external craniotomy. Results: The overall survival (OS) and disease-free survival (DFS) rates at 5 years were 87% and 71%, respectively, with mean follow-up of 45.4 ± 26.5 months. The complication rate was 18.8% with 4 cases of meningitis. Pathological analysis showed positive margins in 26.8%, notably on the dura-mater and periorbita, without impairment of OS or DFS. Forty-eight patients received adjuvant radiotherapy on T ± N. Ten patients had a recurrence (18.9%). Six patients died of their disease. Prophylactic neck irradiation seemed to reduce the recurrence rate. Conclusion: Exclusively endoscopic treatment proved efficient and reliable in a large controlled series.

langue originale	Anglais
Pages (de - à)	1000-1007
Nombre de pages	8
journal	Head and Neck
Volume	40
Numéro de publication	5
Les DOIs	https://doi.org/10.1002/hed.25064
état	Publié - 1 mai 2018
Modification externe	Oui

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10.1002/hed.25064

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de Gabory, L., Verillaud, B., Rumeau, C., Herman, P., Jankowski, R., Michel, J., de Kermadec, H., Coste, A., Mortuaire, G., Righini, C., Reyt, E., Choussy, O., Trévillot, V., Crampette, L., Serrano, E., Tsaranazy, A., Bastier, P. L., & Vergez, S. (2018). Multicenter assessment of exclusive endoscopic endonasal approach for the treatment of 53 olfactory neuroblastomas. Head and Neck, 40(5), 1000-1007. https://doi.org/10.1002/hed.25064

@article{fd701cf2bd1e466ca9c7235cff0c81e0,

title = "Multicenter assessment of exclusive endoscopic endonasal approach for the treatment of 53 olfactory neuroblastomas",

abstract = "Background: Given the particularities of olfactory neuroblastoma (ONB) and the lack of studies on the subject, a multicenter collaborative study was conducted to assess treatment strategy. Methods: Fifty-three patients with ONB were included from the French Rare Head and Neck Cancer Expert Network (REFCOR) database: 16T1, 8T2, 19T3, and 10T4. All cases were treated endoscopically with skull base removal and repair in 26 cases (49%) and without external craniotomy. Results: The overall survival (OS) and disease-free survival (DFS) rates at 5 years were 87% and 71%, respectively, with mean follow-up of 45.4 ± 26.5 months. The complication rate was 18.8% with 4 cases of meningitis. Pathological analysis showed positive margins in 26.8%, notably on the dura-mater and periorbita, without impairment of OS or DFS. Forty-eight patients received adjuvant radiotherapy on T ± N. Ten patients had a recurrence (18.9%). Six patients died of their disease. Prophylactic neck irradiation seemed to reduce the recurrence rate. Conclusion: Exclusively endoscopic treatment proved efficient and reliable in a large controlled series.",

keywords = "endoscopic surgery, neuroblastoma, olfactory cleft, sinus cancer",

author = "{de Gabory}, Ludovic and Benjamin Verillaud and C{\'e}cile Rumeau and Philippe Herman and Roger Jankowski and Justin Michel and {de Kermadec}, H{\'e}lo{\"i}se and Andr{\'e} Coste and Geoffrey Mortuaire and Christian Righini and Emile Reyt and Olivier Choussy and Vincent Tr{\'e}villot and Louis Crampette and Elie Serrano and Anjarasoa Tsaranazy and Bastier, {Pierre Louis} and Sebastien Vergez",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",

year = "2018",

month = may,

day = "1",

doi = "10.1002/hed.25064",

language = "English",

volume = "40",

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de Gabory, L, Verillaud, B, Rumeau, C, Herman, P, Jankowski, R, Michel, J, de Kermadec, H, Coste, A, Mortuaire, G, Righini, C, Reyt, E, Choussy, O, Trévillot, V, Crampette, L, Serrano, E, Tsaranazy, A, Bastier, PL & Vergez, S 2018, 'Multicenter assessment of exclusive endoscopic endonasal approach for the treatment of 53 olfactory neuroblastomas', Head and Neck, VOL. 40, Numéro 5, p. 1000-1007. https://doi.org/10.1002/hed.25064

TY - JOUR

T1 - Multicenter assessment of exclusive endoscopic endonasal approach for the treatment of 53 olfactory neuroblastomas

AU - de Gabory, Ludovic

AU - Verillaud, Benjamin

AU - Rumeau, Cécile

AU - Herman, Philippe

AU - Jankowski, Roger

AU - Michel, Justin

AU - de Kermadec, Héloïse

AU - Coste, André

AU - Mortuaire, Geoffrey

AU - Righini, Christian

AU - Reyt, Emile

AU - Choussy, Olivier

AU - Trévillot, Vincent

AU - Crampette, Louis

AU - Serrano, Elie

AU - Tsaranazy, Anjarasoa

AU - Bastier, Pierre Louis

AU - Vergez, Sebastien

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background: Given the particularities of olfactory neuroblastoma (ONB) and the lack of studies on the subject, a multicenter collaborative study was conducted to assess treatment strategy. Methods: Fifty-three patients with ONB were included from the French Rare Head and Neck Cancer Expert Network (REFCOR) database: 16T1, 8T2, 19T3, and 10T4. All cases were treated endoscopically with skull base removal and repair in 26 cases (49%) and without external craniotomy. Results: The overall survival (OS) and disease-free survival (DFS) rates at 5 years were 87% and 71%, respectively, with mean follow-up of 45.4 ± 26.5 months. The complication rate was 18.8% with 4 cases of meningitis. Pathological analysis showed positive margins in 26.8%, notably on the dura-mater and periorbita, without impairment of OS or DFS. Forty-eight patients received adjuvant radiotherapy on T ± N. Ten patients had a recurrence (18.9%). Six patients died of their disease. Prophylactic neck irradiation seemed to reduce the recurrence rate. Conclusion: Exclusively endoscopic treatment proved efficient and reliable in a large controlled series.

AB - Background: Given the particularities of olfactory neuroblastoma (ONB) and the lack of studies on the subject, a multicenter collaborative study was conducted to assess treatment strategy. Methods: Fifty-three patients with ONB were included from the French Rare Head and Neck Cancer Expert Network (REFCOR) database: 16T1, 8T2, 19T3, and 10T4. All cases were treated endoscopically with skull base removal and repair in 26 cases (49%) and without external craniotomy. Results: The overall survival (OS) and disease-free survival (DFS) rates at 5 years were 87% and 71%, respectively, with mean follow-up of 45.4 ± 26.5 months. The complication rate was 18.8% with 4 cases of meningitis. Pathological analysis showed positive margins in 26.8%, notably on the dura-mater and periorbita, without impairment of OS or DFS. Forty-eight patients received adjuvant radiotherapy on T ± N. Ten patients had a recurrence (18.9%). Six patients died of their disease. Prophylactic neck irradiation seemed to reduce the recurrence rate. Conclusion: Exclusively endoscopic treatment proved efficient and reliable in a large controlled series.

KW - endoscopic surgery

KW - neuroblastoma

KW - olfactory cleft

KW - sinus cancer

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U2 - 10.1002/hed.25064

DO - 10.1002/hed.25064

M3 - Article

C2 - 29356209

AN - SCOPUS:85045744928

SN - 1043-3074

VL - 40

SP - 1000

EP - 1007

JO - Head and Neck

JF - Head and Neck

IS - 5

ER -