Multifocal in situ mantle cell neoplasia of the ileocecal region: a case report with simultaneous nodal and extranodal involvement

Natacha Joyon, Christina Kanaan, Sophie Cotteret, Isabelle Sourrouille, Jean Yves Scoazec, Peggy Dartigues

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    Résumé

    In situ mantle cell neoplasia (ISMCN) is a rare entity of disputed clinical significance. We report an additional case, unusual by its presentation in the large intestine and its multifocal involvement of several nodal and extranodal sites. The diagnosis was made in a 46-year-old male patient from a surgical specimen resected for cecal adenocarcinoma. Gross examination showed multiple small polypoid lesions surrounding the ileocecal valve, corresponding to lymphoid aggregates with hyperplastic follicles. Numerous cyclin D1/SOX11+ lymphoid cells, harboring the t(11;14)(q13;q32) translocation, were present in the inner layers of mantle zones. The same lesions were found in the ileum, the appendix, and the regional lymph nodes. The final diagnosis was multifocal ISMCN of the ileocecal region, with both nodal and extra-nodal involvement. A simple surveillance was decided. Our observation expands the clinical spectrum of the disease and underlines the necessity to closely examine even normal-appearing reactive lymphoid tissues.

    langue originaleAnglais
    Pages (de - à)1037-1040
    Nombre de pages4
    journalVirchows Archiv
    Volume479
    Numéro de publication5
    Les DOIs
    étatPublié - 1 nov. 2021

    Contient cette citation