Multiple loci on 8q24 associated with prostate cancer susceptibility

Ali Amin Al Olama; Zsofia Kote-Jarai; Graham G. Giles; Michelle Guy; Jonathan Morrison; Gianluca Severi; Daniel A. Leongamornlert; Malgorzata Tymrakiewicz; Sameer Jhavar; Ed Saunders; John L. Hopper; Melissa C. Southey; Kenneth R. Muir; Dallas R. English; David P. Dearnaley; Audrey T. Ardern-Jones; Amanda L. Hall; Lynne T. O'Brien; Rosemary A. Wilkinson; Emma Sawyer; Artitaya Lophatananon; Alan Horwich; Robert A. Huddart; Vincent S. Khoo; Christopher C. Parker; Christopher J. Woodhouse; Alan Thompson; Tim Christmas; Chris Ogden; Colin Cooper; Jenny L. Donovan; Freddie C. Hamdy; David E. Neal; Rosalind A. Eeles; Douglas F. Easton

doi:10.1038/ng.452

Multiple loci on 8q24 associated with prostate cancer susceptibility

Ali Amin Al Olama, Zsofia Kote-Jarai, Graham G. Giles, Michelle Guy, Jonathan Morrison, Gianluca Severi, Daniel A. Leongamornlert, Malgorzata Tymrakiewicz, Sameer Jhavar, Ed Saunders, John L. Hopper, Melissa C. Southey, Kenneth R. Muir, Dallas R. English, David P. Dearnaley, Audrey T. Ardern-Jones, Amanda L. Hall, Lynne T. O'Brien, Rosemary A. Wilkinson, Emma SawyerArtitaya Lophatananon, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Christopher J. Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin Cooper, Jenny L. Donovan, Freddie C. Hamdy, David E. Neal, Rosalind A. Eeles, Douglas F. Easton

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

258 Citations (Scopus)

Résumé

Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 × 10 8; rs620861: OR = 0.90, P = 4.8 × 10 8). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.

langue originale	Anglais
Pages (de - à)	1058-1060
Nombre de pages	3
journal	Nature Genetics
Volume	41
Numéro de publication	10
Les DOIs	https://doi.org/10.1038/ng.452
état	Publié - 1 oct. 2009
Modification externe	Oui

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10.1038/ng.452

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Al Olama, A. A., Kote-Jarai, Z., Giles, G. G., Guy, M., Morrison, J., Severi, G., Leongamornlert, D. A., Tymrakiewicz, M., Jhavar, S., Saunders, E., Hopper, J. L., Southey, M. C., Muir, K. R., English, D. R., Dearnaley, D. P., Ardern-Jones, A. T., Hall, A. L., O'Brien, L. T., Wilkinson, R. A., ... Easton, D. F. (2009). Multiple loci on 8q24 associated with prostate cancer susceptibility. Nature Genetics, 41(10), 1058-1060. https://doi.org/10.1038/ng.452

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title = "Multiple loci on 8q24 associated with prostate cancer susceptibility",

abstract = "Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 × 10 8; rs620861: OR = 0.90, P = 4.8 × 10 8). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.",

author = "{Al Olama}, {Ali Amin} and Zsofia Kote-Jarai and Giles, {Graham G.} and Michelle Guy and Jonathan Morrison and Gianluca Severi and Leongamornlert, {Daniel A.} and Malgorzata Tymrakiewicz and Sameer Jhavar and Ed Saunders and Hopper, {John L.} and Southey, {Melissa C.} and Muir, {Kenneth R.} and English, {Dallas R.} and Dearnaley, {David P.} and Ardern-Jones, {Audrey T.} and Hall, {Amanda L.} and O'Brien, {Lynne T.} and Wilkinson, {Rosemary A.} and Emma Sawyer and Artitaya Lophatananon and Alan Horwich and Huddart, {Robert A.} and Khoo, {Vincent S.} and Parker, {Christopher C.} and Woodhouse, {Christopher J.} and Alan Thompson and Tim Christmas and Chris Ogden and Colin Cooper and Donovan, {Jenny L.} and Hamdy, {Freddie C.} and Neal, {David E.} and Eeles, {Rosalind A.} and Easton, {Douglas F.}",

year = "2009",

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doi = "10.1038/ng.452",

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Al Olama, AA, Kote-Jarai, Z, Giles, GG, Guy, M, Morrison, J, Severi, G, Leongamornlert, DA, Tymrakiewicz, M, Jhavar, S, Saunders, E, Hopper, JL, Southey, MC, Muir, KR, English, DR, Dearnaley, DP, Ardern-Jones, AT, Hall, AL, O'Brien, LT, Wilkinson, RA, Sawyer, E, Lophatananon, A, Horwich, A, Huddart, RA, Khoo, VS, Parker, CC, Woodhouse, CJ, Thompson, A, Christmas, T, Ogden, C, Cooper, C, Donovan, JL, Hamdy, FC, Neal, DE, Eeles, RA & Easton, DF 2009, 'Multiple loci on 8q24 associated with prostate cancer susceptibility', Nature Genetics, VOL. 41, Numéro 10, p. 1058-1060. https://doi.org/10.1038/ng.452

TY - JOUR

T1 - Multiple loci on 8q24 associated with prostate cancer susceptibility

AU - Al Olama, Ali Amin

AU - Kote-Jarai, Zsofia

AU - Giles, Graham G.

AU - Guy, Michelle

AU - Morrison, Jonathan

AU - Severi, Gianluca

AU - Leongamornlert, Daniel A.

AU - Tymrakiewicz, Malgorzata

AU - Jhavar, Sameer

AU - Saunders, Ed

AU - Hopper, John L.

AU - Southey, Melissa C.

AU - Muir, Kenneth R.

AU - English, Dallas R.

AU - Dearnaley, David P.

AU - Ardern-Jones, Audrey T.

AU - Hall, Amanda L.

AU - O'Brien, Lynne T.

AU - Wilkinson, Rosemary A.

AU - Sawyer, Emma

AU - Lophatananon, Artitaya

AU - Horwich, Alan

AU - Huddart, Robert A.

AU - Khoo, Vincent S.

AU - Parker, Christopher C.

AU - Woodhouse, Christopher J.

AU - Thompson, Alan

AU - Christmas, Tim

AU - Ogden, Chris

AU - Cooper, Colin

AU - Donovan, Jenny L.

AU - Hamdy, Freddie C.

AU - Neal, David E.

AU - Eeles, Rosalind A.

AU - Easton, Douglas F.

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 × 10 8; rs620861: OR = 0.90, P = 4.8 × 10 8). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.

AB - Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 × 10 8; rs620861: OR = 0.90, P = 4.8 × 10 8). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.

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JO - Nature Genetics

JF - Nature Genetics

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