NADPH oxidases: New actors in thyroid cancer?

Rabii Ameziane-El-Hassani, Martin Schlumberger, Corinne Dupuy

Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

74 Citations (Scopus)

Résumé

Hydrogen peroxide (H2 O2) is a crucial substrate for thyroid peroxidase, a key enzyme involved in thyroid hormone synthesis. However, as a potent oxidant, H2 O2 might also be responsible for the high level of oxidative DNA damage observed in thyroid tissues, such as DNA base lesions and strand breakages, which promote chromosomal instability and contribute to the development of tumours. Although the role of H2 O2 in thyroid hormone synthesis is well established, its precise mechanisms of action in pathological processes are still under investigation. The NADPH oxidase/dual oxidase family are the only oxidoreductases whose primary function is to produce reactive oxygen species. As such, the function and expression of these enzymes are tightly regulated. Thyrocytes express dual oxidase 2, which produces most of the H2 O2 for thyroid hormone synthesis. Thyrocytes also express dual oxidase 1 and NADPH oxidase 4, but the roles of these enzymes are still unknown. Here, we review the structure, expression, localization and function of these enzymes. We focus on their potential role in thyroid cancer, which is characterized by increased expression of these enzymes.

langue originaleAnglais
Pages (de - à)485-494
Nombre de pages10
journalNature Reviews Endocrinology
Volume12
Numéro de publication8
Les DOIs
étatPublié - 1 août 2016
Modification externeOui

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