@inproceedings{664da28316a446fca4cf807190f6b799,
title = "Nanosecond-duration electric pulses open nanometer-size pores in cell plasma membrane",
abstract = "We found that ultra-short electric pulses (60 or 600 ns duration) applied to mammalian cells cause profound, dose-dependent increase of plasma membrane electrical conductance. This effect is detectable even minutes after the exposure and is explained by formation of long-lived, voltagesensitive, inward-rectifying pores of nanometer diameter ({"}nanopores{"}). The phenomenon of nanoelectroporation and the extended lifetime of nanopores can also be demonstrated by a surge of Tl+ uptake in the presence of K+ channel blockers, as well as in CHO cells that express no endogenous voltage-gated K+ channels. Due to their long lifetime, nanopores can have significant impact on cell physiology.",
keywords = "Cell membrane, Electroporation, Lipidic pores",
author = "Pakhomov, {A. G.} and Ibey, {B. L.} and Bowman, {A. M.} and Andre, {F. M.} and Pakhomova, {O. N.}",
year = "2009",
month = jan,
day = "1",
doi = "10.1007/978-3-642-03895-2_6",
language = "English",
isbn = "9783642038945",
series = "IFMBE Proceedings",
publisher = "Springer Verlag",
number = "13",
pages = "17--20",
booktitle = "World Congress on Medical Physics and Biomedical Engineering",
edition = "13",
note = "World Congress on Medical Physics and Biomedical Engineering: Special Topics and Workshops ; Conference date: 07-09-2009 Through 12-09-2009",
}