@article{db16049a6e5a42598bd81ad1b73d5b65,
title = "New strategies and designs in pancreatic cancer research: Consensus guidelines report from a European expert panel",
abstract = "Although the treatment of pancreatic ductal adenocarcinoma (PDAC) remains a huge challenge, it is entering a new era with the development of new strategies and trial designs. Because there is an increasing number of novel therapeutic agents and potential combinations available to test in patients with PDAC, the identification of robust prognostic and predictive markers and of new targets and relevant pathways is a top priority as well as the design of adequate trials incorporating molecular-driven hypothesis. We presently report a consensus strategy for research in pancreatic cancer that was developed by a multidisciplinary panel of experts from different European institutions and collaborative groups involved in pancreatic cancer. The expert panel embraces the concept of exploratory early proof of concept studies, based on the prediction of response to novel agents and combinations, and randomised phase II studies permitting the selection of the best therapeutic approach to go forward into phase III, where the recommended primary end point remains overall survival. Trials should contain as many translational components as possible, relying on standardised tissue and blood processing and robust biobanking, and including dynamic imaging. Attention should not only be paid to the pancreatic cancer cells but also to microenvironmental factors and stem/stellate cells.",
keywords = "Chemoradiation, FOLFIRINOX, Pancreatic cancer, Preclinical, Research strategy",
author = "{Van Laethem}, {J. L.} and C. Verslype and Iovanna, {J. L.} and P. Michl and T. Conroy and C. Louvet and P. Hamme and E. Mitry and M. Ducreux and T. Maraculla and W. Uhl and {Van Tienhoven}, G. and Bachet, {J. B.} and Chal, {R. Mar{\'e}} and A. Hendlisz and M. Bali and P. Demetter and F. Ulrich and D. Aust and J. Luttges and M. Peeters and M. Mauer and A. Roth and Neoptolemos, {J. P.} and M. Lutz",
note = "Funding Information: 1Gastrointestinal Cancer Unit, H{\^o}pital Erasme, Universit{\'e} Libre de Bruxelles, Brussels; 2Department of Hepatology, Universitair Ziekenhuis Gasthuisberg, Leuven, Belgium; 3Institut National de la Sant{\'e} et de la Recherche M{\'e}dicale, Marseille, France;4Department of Gastroenterology and Endocrinology, University of Marburg, Marburg, Germany; 5Nancy University and Department of Medical Oncology, Centre Alexis Vautrin, Nancy; 6Digestive Surgery Department, Institut Mutualiste Montsouris, Paris; 7Gastroenterology Department, H{\^o}pital Beaujon, Clichy; 8Medical Oncology Department, Institut Curie, H{\^o}pital Ren{\'e}-Huguenin, Saint-Cloud; 9Digestive Oncology Department, Institut G. Roussy, Villejuif, France; 10Medical Oncology Department, Hospital Vall d{\textquoteright}Hebron, Barcelona, Spain; 11Department of Surgery, St Josef-Hospital, Ruhr-University, Bochum, Germany; 12Department of Radiation Oncology, Academic Medical Centre, Amsterdam, The Netherlands; 13Department of Gastroenterology, H{\^o}pital Piti{\'e} Salp{\^e}tri{\`e}re, Assistance Publique-H{\^o}pitaux de Paris, Paris, France; 14Department of Gastroenterology and Hepato-Pancreatology, Gastrointestinal Cancer Unit, H{\^o}pital Universitaire Erasme, Brussels; 15Department of Gastroenterology, Institut J. Bordet, Brussels; 16Department of Medical Imaging, H{\^o}pital Erasme, Brussels, Belgium; 17Department of General and Visceral Surgery, J. W. Goethe University Medical Center, Frankfurt; 18Institute of Pathology, University Hospital Carl Gustav Carus, Dresden; 19Caritasklinik St Theresia, Saarbr{\"u}cken, Germany; 20Department of Oncology, Universitair Ziekenhuis Antwerpen, Edegem; 21European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium; 22Department of Surgery, Clinic for Visceral and Transplantation Surgery, H{\^o}pital Universitaire de Gen{\`e}ve, Geneva, Switzerland; 23Department of Surgery, University of Liverpool, Liverpool, UK",
year = "2012",
month = jan,
day = "1",
doi = "10.1093/annonc/mdr351",
language = "English",
volume = "23",
pages = "570--576",
journal = "Annals of Oncology",
issn = "0923-7534",
number = "3",
}