Next generation sequencing (NGS): A revolutionary technology in pharmacogenomics and personalized medicine in cancer

Stefania Morganti, Paolo Tarantino, Emanuela Ferraro, Paolo D’Amico, Bruno Achutti Duso, Giuseppe Curigliano

Résultats de recherche: Le chapitre dans un livre, un rapport, une anthologie ou une collection!!ChapterRevue par des pairs

138 Citations (Scopus)

Résumé

Following the completion of the Human Genome Project in 2003, research in oncology has progressively focused on the sequencing of cancer genomes, with the aim of better understanding the genetic basis of oncogenesis and identifying actionable alterations. The development of next-generation-sequencing (NGS) techniques, commercially available since 2006, allowed for a cost- and time-effective sequencing of tumor DNA, leading to a “genomic era” of cancer research and treatment. NGS provided a significant step forward in Personalized Medicine (PM) by enabling the detection of somatic driver mutations, resistance mechanisms, quantification of mutational burden, germline mutations which settled the foundation of a new approach in cancer care. In this chapter we discuss the history, available techniques and applications of NGS in oncology, with a particular referral to the PM approach and the emerging role of the research field of pharmacogenomics.

langue originaleAnglais
titreAdvances in Experimental Medicine and Biology
EditeurSpringer
Pages9-30
Nombre de pages22
Les DOIs
étatPublié - 1 janv. 2019
Modification externeOui

Série de publications

NomAdvances in Experimental Medicine and Biology
Volume1168
ISSN (imprimé)0065-2598
ISSN (Electronique)2214-8019

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