No Geographical Inequalities in Survival for Sarcoma Patients in France: A Reference Networks’ Outcome?

Yohan Fayet; Christine Chevreau; Gauthier Decanter; Cécile Dalban; Pierre Meeus; Sébastien Carrère; Leila Haddag-Miliani; François Le Loarer; Sylvain Causeret; Daniel Orbach; Michelle Kind; Louis Romée Le Nail; Gwenaël Ferron; Hélène Labrosse; Loïc Chaigneau; François Bertucci; Jean Christophe Ruzic; Valérie Le Brun Ly; Fadila Farsi; Emmanuelle Bompas; Sabine Noal; Aurore Vozy; Agnes Ducoulombier; Clément Bonnet; Sylvie Chabaud; Françoise Ducimetière; Camille Tlemsani; Mickaël Ropars; Olivier Collard; Paul Michelin; Justine Gantzer; Pascale Dubray-Longeras; Maria Rios; Pauline Soibinet; Axel Le Cesne; Florence Duffaud; Marie Karanian; François Gouin; Raphaël Tétreau; Charles Honoré; Jean Michel Coindre; Isabelle Ray-Coquard; Sylvie Bonvalot; Jean Yves Blay

doi:10.3390/cancers14112620

No Geographical Inequalities in Survival for Sarcoma Patients in France: A Reference Networks’ Outcome?

Yohan Fayet, Christine Chevreau, Gauthier Decanter, Cécile Dalban, Pierre Meeus, Sébastien Carrère, Leila Haddag-Miliani, François Le Loarer, Sylvain Causeret, Daniel Orbach, Michelle Kind, Louis Romée Le Nail, Gwenaël Ferron, Hélène Labrosse, Loïc Chaigneau, François Bertucci, Jean Christophe Ruzic, Valérie Le Brun Ly, Fadila Farsi, Emmanuelle BompasSabine Noal, Aurore Vozy, Agnes Ducoulombier, Clément Bonnet, Sylvie Chabaud, Françoise Ducimetière, Camille Tlemsani, Mickaël Ropars, Olivier Collard, Paul Michelin, Justine Gantzer, Pascale Dubray-Longeras, Maria Rios, Pauline Soibinet, Axel Le Cesne, Florence Duffaud, Marie Karanian, François Gouin, Raphaël Tétreau, Charles Honoré, Jean Michel Coindre, Isabelle Ray-Coquard, Sylvie Bonvalot, Jean Yves Blay

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

3 Citations (Scopus)

Résumé

The national reference network NETSARC+ provides remote access to specialized diagnosis and the Multidisciplinary Tumour Board (MTB) to improve the management and survival of sarcoma patients in France. The IGéAS research program aims to assess the potential of this innovative organization to address geographical inequalities in cancer management. Using the IGéAS cohort built from the nationwide NETSARC+ database, the individual, clinical, and geographical determinants of the 3-year overall survival of sarcoma patients in France were analyzed. The survival analysis was focused on patients diagnosed in 2013 (n = 2281) to ensure sufficient hindsight to collect patient follow-up. Our study included patients with bone (16.8%), soft-tissue (69%), and visceral (14.2%) sarcomas, with a median age of 61.8 years. The overall survival was not associated with geographical variables after adjustment for individual and clinical factors. The lower survival in precarious population districts [HR 1.23, 95% CI 1.02 to 1.48] in comparison to wealthy metropolitan areas (HR = 1) found in univariable analysis was due to the worst clinical presentation at diagnosis of patients. The place of residence had no impact on sarcoma patients’ survival, in the context of the national organization driven by the reference network. Following previous findings, this suggests the ability of this organization to go through geographical barriers usually impeding the optimal management of cancer patients.

langue originale	Anglais
Numéro d'article	2620
journal	Cancers
Volume	14
Numéro de publication	11
Les DOIs	https://doi.org/10.3390/cancers14112620
état	Publié - 1 juin 2022

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10.3390/cancers14112620

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Fayet, Y., Chevreau, C., Decanter, G., Dalban, C., Meeus, P., Carrère, S., Haddag-Miliani, L., Loarer, F. L., Causeret, S., Orbach, D., Kind, M., Nail, L. R. L., Ferron, G., Labrosse, H., Chaigneau, L., Bertucci, F., Ruzic, J. C., Ly, V. L. B., Farsi, F., ... Blay, J. Y. (2022). No Geographical Inequalities in Survival for Sarcoma Patients in France: A Reference Networks’ Outcome? Cancers, 14(11), Article 2620. https://doi.org/10.3390/cancers14112620

@article{de1185893da34f438b8806f8c18ca7db,

title = "No Geographical Inequalities in Survival for Sarcoma Patients in France: A Reference Networks{\textquoteright} Outcome?",

abstract = "The national reference network NETSARC+ provides remote access to specialized diagnosis and the Multidisciplinary Tumour Board (MTB) to improve the management and survival of sarcoma patients in France. The IG{\'e}AS research program aims to assess the potential of this innovative organization to address geographical inequalities in cancer management. Using the IG{\'e}AS cohort built from the nationwide NETSARC+ database, the individual, clinical, and geographical determinants of the 3-year overall survival of sarcoma patients in France were analyzed. The survival analysis was focused on patients diagnosed in 2013 (n = 2281) to ensure sufficient hindsight to collect patient follow-up. Our study included patients with bone (16.8%), soft-tissue (69%), and visceral (14.2%) sarcomas, with a median age of 61.8 years. The overall survival was not associated with geographical variables after adjustment for individual and clinical factors. The lower survival in precarious population districts [HR 1.23, 95% CI 1.02 to 1.48] in comparison to wealthy metropolitan areas (HR = 1) found in univariable analysis was due to the worst clinical presentation at diagnosis of patients. The place of residence had no impact on sarcoma patients{\textquoteright} survival, in the context of the national organization driven by the reference network. Following previous findings, this suggests the ability of this organization to go through geographical barriers usually impeding the optimal management of cancer patients.",

keywords = "France, rare cancers, reference networks, remoteness, social deprivation, spatial inequalities",

author = "Yohan Fayet and Christine Chevreau and Gauthier Decanter and C{\'e}cile Dalban and Pierre Meeus and S{\'e}bastien Carr{\`e}re and Leila Haddag-Miliani and Loarer, {Fran{\c c}ois Le} and Sylvain Causeret and Daniel Orbach and Michelle Kind and Nail, {Louis Rom{\'e}e Le} and Gwena{\"e}l Ferron and H{\'e}l{\`e}ne Labrosse and Lo{\"i}c Chaigneau and Fran{\c c}ois Bertucci and Ruzic, {Jean Christophe} and Ly, {Val{\'e}rie Le Brun} and Fadila Farsi and Emmanuelle Bompas and Sabine Noal and Aurore Vozy and Agnes Ducoulombier and Cl{\'e}ment Bonnet and Sylvie Chabaud and Fran{\c c}oise Ducimeti{\`e}re and Camille Tlemsani and Micka{\"e}l Ropars and Olivier Collard and Paul Michelin and Justine Gantzer and Pascale Dubray-Longeras and Maria Rios and Pauline Soibinet and Cesne, {Axel Le} and Florence Duffaud and Marie Karanian and Fran{\c c}ois Gouin and Rapha{\"e}l T{\'e}treau and Charles Honor{\'e} and Coindre, {Jean Michel} and Isabelle Ray-Coquard and Sylvie Bonvalot and Blay, {Jean Yves}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jun,

day = "1",

doi = "10.3390/cancers14112620",

language = "English",

volume = "14",

journal = "Cancers",

issn = "2072-6694",

number = "11",

}

Fayet, Y, Chevreau, C, Decanter, G, Dalban, C, Meeus, P, Carrère, S, Haddag-Miliani, L, Loarer, FL, Causeret, S, Orbach, D, Kind, M, Nail, LRL, Ferron, G, Labrosse, H, Chaigneau, L, Bertucci, F, Ruzic, JC, Ly, VLB, Farsi, F, Bompas, E, Noal, S, Vozy, A, Ducoulombier, A, Bonnet, C, Chabaud, S, Ducimetière, F, Tlemsani, C, Ropars, M, Collard, O, Michelin, P, Gantzer, J, Dubray-Longeras, P, Rios, M, Soibinet, P, Cesne, AL, Duffaud, F, Karanian, M, Gouin, F, Tétreau, R, Honoré, C, Coindre, JM, Ray-Coquard, I, Bonvalot, S & Blay, JY 2022, 'No Geographical Inequalities in Survival for Sarcoma Patients in France: A Reference Networks’ Outcome?', Cancers, VOL. 14, Numéro 11, 2620. https://doi.org/10.3390/cancers14112620

TY - JOUR

T1 - No Geographical Inequalities in Survival for Sarcoma Patients in France

T2 - A Reference Networks’ Outcome?

AU - Fayet, Yohan

AU - Chevreau, Christine

AU - Decanter, Gauthier

AU - Dalban, Cécile

AU - Meeus, Pierre

AU - Carrère, Sébastien

AU - Haddag-Miliani, Leila

AU - Loarer, François Le

AU - Causeret, Sylvain

AU - Orbach, Daniel

AU - Kind, Michelle

AU - Nail, Louis Romée Le

AU - Ferron, Gwenaël

AU - Labrosse, Hélène

AU - Chaigneau, Loïc

AU - Bertucci, François

AU - Ruzic, Jean Christophe

AU - Ly, Valérie Le Brun

AU - Farsi, Fadila

AU - Bompas, Emmanuelle

AU - Noal, Sabine

AU - Vozy, Aurore

AU - Ducoulombier, Agnes

AU - Bonnet, Clément

AU - Chabaud, Sylvie

AU - Ducimetière, Françoise

AU - Tlemsani, Camille

AU - Ropars, Mickaël

AU - Collard, Olivier

AU - Michelin, Paul

AU - Gantzer, Justine

AU - Dubray-Longeras, Pascale

AU - Rios, Maria

AU - Soibinet, Pauline

AU - Cesne, Axel Le

AU - Duffaud, Florence

AU - Karanian, Marie

AU - Gouin, François

AU - Tétreau, Raphaël

AU - Honoré, Charles

AU - Coindre, Jean Michel

AU - Ray-Coquard, Isabelle

AU - Bonvalot, Sylvie

AU - Blay, Jean Yves

PY - 2022/6/1

Y1 - 2022/6/1

N2 - The national reference network NETSARC+ provides remote access to specialized diagnosis and the Multidisciplinary Tumour Board (MTB) to improve the management and survival of sarcoma patients in France. The IGéAS research program aims to assess the potential of this innovative organization to address geographical inequalities in cancer management. Using the IGéAS cohort built from the nationwide NETSARC+ database, the individual, clinical, and geographical determinants of the 3-year overall survival of sarcoma patients in France were analyzed. The survival analysis was focused on patients diagnosed in 2013 (n = 2281) to ensure sufficient hindsight to collect patient follow-up. Our study included patients with bone (16.8%), soft-tissue (69%), and visceral (14.2%) sarcomas, with a median age of 61.8 years. The overall survival was not associated with geographical variables after adjustment for individual and clinical factors. The lower survival in precarious population districts [HR 1.23, 95% CI 1.02 to 1.48] in comparison to wealthy metropolitan areas (HR = 1) found in univariable analysis was due to the worst clinical presentation at diagnosis of patients. The place of residence had no impact on sarcoma patients’ survival, in the context of the national organization driven by the reference network. Following previous findings, this suggests the ability of this organization to go through geographical barriers usually impeding the optimal management of cancer patients.

AB - The national reference network NETSARC+ provides remote access to specialized diagnosis and the Multidisciplinary Tumour Board (MTB) to improve the management and survival of sarcoma patients in France. The IGéAS research program aims to assess the potential of this innovative organization to address geographical inequalities in cancer management. Using the IGéAS cohort built from the nationwide NETSARC+ database, the individual, clinical, and geographical determinants of the 3-year overall survival of sarcoma patients in France were analyzed. The survival analysis was focused on patients diagnosed in 2013 (n = 2281) to ensure sufficient hindsight to collect patient follow-up. Our study included patients with bone (16.8%), soft-tissue (69%), and visceral (14.2%) sarcomas, with a median age of 61.8 years. The overall survival was not associated with geographical variables after adjustment for individual and clinical factors. The lower survival in precarious population districts [HR 1.23, 95% CI 1.02 to 1.48] in comparison to wealthy metropolitan areas (HR = 1) found in univariable analysis was due to the worst clinical presentation at diagnosis of patients. The place of residence had no impact on sarcoma patients’ survival, in the context of the national organization driven by the reference network. Following previous findings, this suggests the ability of this organization to go through geographical barriers usually impeding the optimal management of cancer patients.

KW - France

KW - rare cancers

KW - reference networks

KW - remoteness

KW - social deprivation

KW - spatial inequalities

UR - http://www.scopus.com/inward/record.url?scp=85130987084&partnerID=8YFLogxK

U2 - 10.3390/cancers14112620

DO - 10.3390/cancers14112620

M3 - Article

AN - SCOPUS:85130987084

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 11

M1 - 2620

ER -