TY - JOUR
T1 - Non-dioxin-like polychlorinated biphenyls (NDL-PCBs) dietary exposure is associated with an increased risk of type 2 diabetes in the European prospective investigation into cancer and nutrition (EPIC) cohort
AU - Ren, Xuan
AU - Nicolas, Geneviève
AU - Frenoy, Pauline
AU - Papier, Keren
AU - Moreno-Iribas, Conchi
AU - Masala, Giovanna
AU - Dahm, Christina C.
AU - Zhang, Jie
AU - Jannasch, Franziska
AU - Schulze, Matthias B.
AU - Weiderpass, Elisabete
AU - Chiodini, Paolo
AU - Vener, Claudia
AU - Vineis, Paolo
AU - Heath, Alicia K.
AU - Ricceri, Fulvio
AU - Colorado-Yohar, Sandra M.
AU - Marques, Chloé
AU - Fiolet, Thibault
AU - Severi, Gianluca
AU - Huybrechts, Inge
AU - Mancini, Francesca Romana
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/11/1
Y1 - 2024/11/1
N2 - Aims/hypothesis: The aim of the present study was to investigate the association between dietary exposures to dioxins, dioxin-like polychlorinated biphenyls (DL-PCBs) and non-dioxin-like polychlorinated biphenyls (NDL-PCBs) and the incidence of type 2 diabetes mellitus (T2DM) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: This prospective cohort study with a median 11.7 years of follow-up, included 318,416 individuals recruited in 21 centers in eight countries. Dietary intake of dioxins and PCBs was calculated by combining EPIC food consumption data with food contamination data from the European Food Safety Authority (EFSA). To identify incident cases of T2DM, a thorough review of various sources including self-reported information, linkage to primary and secondary care registers, drug registers, hospital admissions, and mortality data was conducted. Associations between dietary intake of dioxins and PCBs and T2DM were evaluated using multivariable Cox regressions. Results: Higher T2DM risk was observed for higher estimated dietary intake of non-dioxin-like PCBs (NDL-PCBs; HR per 1 SD increment = 1.03 [95 %CI 1.01;1.04], and HR (Q4 vs Q1) = 1.15 [1.08;1.22], P-trend < 0.001). The results were consistent in analyses stratified by gender, body mass index, country, median follow-up, or self-reported hypertension and hyperlipidemia, as well as when adjusting for fat intake. No consistent association was observed between dioxins+DL-PCBs intake and T2DM risk. Conclusion / interpretation: Results obtained in this large European prospective study indicate a positive and linear association between dietary intake of NDL-PCBs and risk of T2DM. This association remained consistent across various stratified and sensitivity analyses. Further studies are warranted to better understand the biological mechanisms underlying this association.
AB - Aims/hypothesis: The aim of the present study was to investigate the association between dietary exposures to dioxins, dioxin-like polychlorinated biphenyls (DL-PCBs) and non-dioxin-like polychlorinated biphenyls (NDL-PCBs) and the incidence of type 2 diabetes mellitus (T2DM) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: This prospective cohort study with a median 11.7 years of follow-up, included 318,416 individuals recruited in 21 centers in eight countries. Dietary intake of dioxins and PCBs was calculated by combining EPIC food consumption data with food contamination data from the European Food Safety Authority (EFSA). To identify incident cases of T2DM, a thorough review of various sources including self-reported information, linkage to primary and secondary care registers, drug registers, hospital admissions, and mortality data was conducted. Associations between dietary intake of dioxins and PCBs and T2DM were evaluated using multivariable Cox regressions. Results: Higher T2DM risk was observed for higher estimated dietary intake of non-dioxin-like PCBs (NDL-PCBs; HR per 1 SD increment = 1.03 [95 %CI 1.01;1.04], and HR (Q4 vs Q1) = 1.15 [1.08;1.22], P-trend < 0.001). The results were consistent in analyses stratified by gender, body mass index, country, median follow-up, or self-reported hypertension and hyperlipidemia, as well as when adjusting for fat intake. No consistent association was observed between dioxins+DL-PCBs intake and T2DM risk. Conclusion / interpretation: Results obtained in this large European prospective study indicate a positive and linear association between dietary intake of NDL-PCBs and risk of T2DM. This association remained consistent across various stratified and sensitivity analyses. Further studies are warranted to better understand the biological mechanisms underlying this association.
KW - Dietary intake
KW - Dioxin-like PCBs (DL-PCBs)
KW - Non-dioxin-like PCBs (NDL-PCBs)
KW - Polychlorinated biphenyls (PCBs);Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85209252588&partnerID=8YFLogxK
U2 - 10.1016/j.diabet.2024.101587
DO - 10.1016/j.diabet.2024.101587
M3 - Article
AN - SCOPUS:85209252588
SN - 1262-3636
VL - 50
JO - Diabetes and Metabolism
JF - Diabetes and Metabolism
IS - 6
M1 - 101587
ER -