Occult cancer in specimens of reduction mammaplasty aimed at symmetrization. A multicentric study of 2718 patients

T. Sorin; J. P. Fyad; E. Delay; P. Rouanet; F. Rimareix; J. L. Houpeau; J. M. Classe; I. Garrido; C. Tunon De Lara; J. Dauplat; C. Bendavid; G. Houvenaeghel; K. B. Clough; I. Sarfati; N. Leymarie; M. Trudel; J. Salleron; F. Guillemin; G. Oldrini; M. Brix; G. Dolivet; E. Simon; J. L. Verhaeghe; F. Marchal

doi:10.1016/j.breast.2015.02.033

Occult cancer in specimens of reduction mammaplasty aimed at symmetrization. A multicentric study of 2718 patients

T. Sorin, J. P. Fyad, E. Delay, P. Rouanet, F. Rimareix, J. L. Houpeau, J. M. Classe, I. Garrido, C. Tunon De Lara, J. Dauplat, C. Bendavid, G. Houvenaeghel, K. B. Clough, I. Sarfati, N. Leymarie, M. Trudel, J. Salleron, F. Guillemin, G. Oldrini, M. BrixG. Dolivet, E. Simon, J. L. Verhaeghe, F. Marchal

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Résumé

Women who have undergone surgical treatment for breast cancer often benefit from a contralateral reduction mammaplasty (CRM) aimed at symmetrization of the contralateral breast unaffected by the initial cancer. In our 7-year multicentric study (12 centers) of 2718 patients, incidence of CRM cancers (CRMc) was 1.47% (n=40) [95% CI 1.05%-2.00%]. The CRMc group had significantly more initial mammary cancers of invasive lobular carcinoma (ILC, 22.5% vs 12.0%) and ductal carcinoma in situ (DCIS, 35.0% vs 21.6%) types than the healthy CRM group (p=0.017). 35.0% (n=14) of patients had en bloc resection; 25.0% (n=10) of surgical specimens were correctly oriented. En bloc resection and orientation of surgical specimens enable precise pinpointing of the CRMc. A salvage lumpectomy may be proposed as an option when margins are invaded. The histological distribution of the 40 CRMc (mean size 12.7mm) was carcinoma in situ (CIS) 70%, ILC 12.5%, invasive ductal carcinoma (IDC) 12.5% and tubular carcinoma (TC) 5.0%.

langue originale	Anglais
Pages (de - à)	272-277
Nombre de pages	6
journal	Breast
Volume	24
Numéro de publication	3
Les DOIs	https://doi.org/10.1016/j.breast.2015.02.033
état	Publié - 1 juin 2015

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10.1016/j.breast.2015.02.033

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Sorin, T., Fyad, J. P., Delay, E., Rouanet, P., Rimareix, F., Houpeau, J. L., Classe, J. M., Garrido, I., Tunon De Lara, C., Dauplat, J., Bendavid, C., Houvenaeghel, G., Clough, K. B., Sarfati, I., Leymarie, N., Trudel, M., Salleron, J., Guillemin, F., Oldrini, G., ... Marchal, F. (2015). Occult cancer in specimens of reduction mammaplasty aimed at symmetrization. A multicentric study of 2718 patients. Breast, 24(3), 272-277. https://doi.org/10.1016/j.breast.2015.02.033

@article{b3ec616535ed4cbe8d6d9e86a4f5e111,

title = "Occult cancer in specimens of reduction mammaplasty aimed at symmetrization. A multicentric study of 2718 patients",

abstract = "Women who have undergone surgical treatment for breast cancer often benefit from a contralateral reduction mammaplasty (CRM) aimed at symmetrization of the contralateral breast unaffected by the initial cancer. In our 7-year multicentric study (12 centers) of 2718 patients, incidence of CRM cancers (CRMc) was 1.47% (n=40) [95% CI 1.05%-2.00%]. The CRMc group had significantly more initial mammary cancers of invasive lobular carcinoma (ILC, 22.5% vs 12.0%) and ductal carcinoma in situ (DCIS, 35.0% vs 21.6%) types than the healthy CRM group (p=0.017). 35.0% (n=14) of patients had en bloc resection; 25.0% (n=10) of surgical specimens were correctly oriented. En bloc resection and orientation of surgical specimens enable precise pinpointing of the CRMc. A salvage lumpectomy may be proposed as an option when margins are invaded. The histological distribution of the 40 CRMc (mean size 12.7mm) was carcinoma in situ (CIS) 70%, ILC 12.5%, invasive ductal carcinoma (IDC) 12.5% and tubular carcinoma (TC) 5.0%.",

keywords = "Breast neoplasms, Breast reconstruction, Incidence study, Mammoplasty, Reconstructive surgical procedures",

author = "T. Sorin and Fyad, {J. P.} and E. Delay and P. Rouanet and F. Rimareix and Houpeau, {J. L.} and Classe, {J. M.} and I. Garrido and {Tunon De Lara}, C. and J. Dauplat and C. Bendavid and G. Houvenaeghel and Clough, {K. B.} and I. Sarfati and N. Leymarie and M. Trudel and J. Salleron and F. Guillemin and G. Oldrini and M. Brix and G. Dolivet and E. Simon and Verhaeghe, {J. L.} and F. Marchal",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = jun,

day = "1",

doi = "10.1016/j.breast.2015.02.033",

language = "English",

volume = "24",

pages = "272--277",

journal = "Breast",

issn = "0960-9776",

number = "3",

}

Sorin, T, Fyad, JP, Delay, E, Rouanet, P, Rimareix, F, Houpeau, JL, Classe, JM, Garrido, I, Tunon De Lara, C, Dauplat, J, Bendavid, C, Houvenaeghel, G, Clough, KB, Sarfati, I, Leymarie, N, Trudel, M, Salleron, J, Guillemin, F, Oldrini, G, Brix, M, Dolivet, G, Simon, E, Verhaeghe, JL & Marchal, F 2015, 'Occult cancer in specimens of reduction mammaplasty aimed at symmetrization. A multicentric study of 2718 patients', Breast, VOL. 24, Numéro 3, p. 272-277. https://doi.org/10.1016/j.breast.2015.02.033

TY - JOUR

T1 - Occult cancer in specimens of reduction mammaplasty aimed at symmetrization. A multicentric study of 2718 patients

AU - Sorin, T.

AU - Fyad, J. P.

AU - Delay, E.

AU - Rouanet, P.

AU - Rimareix, F.

AU - Houpeau, J. L.

AU - Classe, J. M.

AU - Garrido, I.

AU - Tunon De Lara, C.

AU - Dauplat, J.

AU - Bendavid, C.

AU - Houvenaeghel, G.

AU - Clough, K. B.

AU - Sarfati, I.

AU - Leymarie, N.

AU - Trudel, M.

AU - Salleron, J.

AU - Guillemin, F.

AU - Oldrini, G.

AU - Brix, M.

AU - Dolivet, G.

AU - Simon, E.

AU - Verhaeghe, J. L.

AU - Marchal, F.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Women who have undergone surgical treatment for breast cancer often benefit from a contralateral reduction mammaplasty (CRM) aimed at symmetrization of the contralateral breast unaffected by the initial cancer. In our 7-year multicentric study (12 centers) of 2718 patients, incidence of CRM cancers (CRMc) was 1.47% (n=40) [95% CI 1.05%-2.00%]. The CRMc group had significantly more initial mammary cancers of invasive lobular carcinoma (ILC, 22.5% vs 12.0%) and ductal carcinoma in situ (DCIS, 35.0% vs 21.6%) types than the healthy CRM group (p=0.017). 35.0% (n=14) of patients had en bloc resection; 25.0% (n=10) of surgical specimens were correctly oriented. En bloc resection and orientation of surgical specimens enable precise pinpointing of the CRMc. A salvage lumpectomy may be proposed as an option when margins are invaded. The histological distribution of the 40 CRMc (mean size 12.7mm) was carcinoma in situ (CIS) 70%, ILC 12.5%, invasive ductal carcinoma (IDC) 12.5% and tubular carcinoma (TC) 5.0%.

AB - Women who have undergone surgical treatment for breast cancer often benefit from a contralateral reduction mammaplasty (CRM) aimed at symmetrization of the contralateral breast unaffected by the initial cancer. In our 7-year multicentric study (12 centers) of 2718 patients, incidence of CRM cancers (CRMc) was 1.47% (n=40) [95% CI 1.05%-2.00%]. The CRMc group had significantly more initial mammary cancers of invasive lobular carcinoma (ILC, 22.5% vs 12.0%) and ductal carcinoma in situ (DCIS, 35.0% vs 21.6%) types than the healthy CRM group (p=0.017). 35.0% (n=14) of patients had en bloc resection; 25.0% (n=10) of surgical specimens were correctly oriented. En bloc resection and orientation of surgical specimens enable precise pinpointing of the CRMc. A salvage lumpectomy may be proposed as an option when margins are invaded. The histological distribution of the 40 CRMc (mean size 12.7mm) was carcinoma in situ (CIS) 70%, ILC 12.5%, invasive ductal carcinoma (IDC) 12.5% and tubular carcinoma (TC) 5.0%.

KW - Breast neoplasms

KW - Breast reconstruction

KW - Incidence study

KW - Mammoplasty

KW - Reconstructive surgical procedures

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U2 - 10.1016/j.breast.2015.02.033

DO - 10.1016/j.breast.2015.02.033

M3 - Article

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AN - SCOPUS:84937642961

SN - 0960-9776

VL - 24

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JO - Breast

JF - Breast

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