TY - JOUR
T1 - Oncological and functional outcomes for transoral robotic surgery following previous radiation treatment for upper aerodigestive tract head and neck cancers. A French multicenter GETTEC group study
AU - Malard, Olivier
AU - Karakachoff, Matilde
AU - Ferron, Christophe
AU - Hans, Stéphane
AU - Vergez, Sébastien
AU - Garrel, Renaud
AU - Gorphe, Philippe
AU - Ramin, Lionel
AU - Santini, Laure
AU - Villeneuve, Alexandre
AU - Lasne-Cardon, Audrey
AU - Espitalier, Florent
AU - Hounkpatin, Audrey
N1 - Publisher Copyright:
© 2024 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
PY - 2024/4/1
Y1 - 2024/4/1
N2 - Background: Transoral robotic surgery (TORS) opens new perspectives. We evaluated the outcomes for patients having undergone TORS after previous radiotherapy. Methods: A retrospective multicenter study (n = 138) in a previously irradiated area between 2009 and 2020. Survival was assessed with the Kaplan–Meier method. Prognostic factors were evaluated using a chi-squared test, Fisher's test, or Wilcoxon's test. Results: The median length of hospital stay was 12.5 days. Bleeding was the most frequent postoperative complication (15.2%, n = 22). Prophylactic vessel ligation did not significantly decrease bleeding. Complications were significantly lower for Tis, T1, and N0 tumors. 91.6% (n = 120) of the patients with a perioperative tracheotomy could be decannulated. Larynx was functional for 65.94% of the patients. The median length of follow-up was 26 months. The 5-year overall and relapse-free survival rates were respectively 59.9% and 43.4%. Conclusion: Oncological and functional results confirmed the value of TORS as a treatment in previously irradiated area.
AB - Background: Transoral robotic surgery (TORS) opens new perspectives. We evaluated the outcomes for patients having undergone TORS after previous radiotherapy. Methods: A retrospective multicenter study (n = 138) in a previously irradiated area between 2009 and 2020. Survival was assessed with the Kaplan–Meier method. Prognostic factors were evaluated using a chi-squared test, Fisher's test, or Wilcoxon's test. Results: The median length of hospital stay was 12.5 days. Bleeding was the most frequent postoperative complication (15.2%, n = 22). Prophylactic vessel ligation did not significantly decrease bleeding. Complications were significantly lower for Tis, T1, and N0 tumors. 91.6% (n = 120) of the patients with a perioperative tracheotomy could be decannulated. Larynx was functional for 65.94% of the patients. The median length of follow-up was 26 months. The 5-year overall and relapse-free survival rates were respectively 59.9% and 43.4%. Conclusion: Oncological and functional results confirmed the value of TORS as a treatment in previously irradiated area.
KW - head and neck cancer
KW - radiotherapy
KW - squamous cell carcinoma
KW - transoral robotic surgery
UR - http://www.scopus.com/inward/record.url?scp=85189269458&partnerID=8YFLogxK
U2 - 10.1002/cam4.7031
DO - 10.1002/cam4.7031
M3 - Article
C2 - 38545809
AN - SCOPUS:85189269458
SN - 2045-7634
VL - 13
JO - Cancer Medicine
JF - Cancer Medicine
IS - 7
M1 - e7031
ER -