TY - JOUR
T1 - Oral cavity squamous cell carcinoma in 260 patients aged 80 years or more
AU - Ortholan, Cécile
AU - Lusinchi, Antoine
AU - Italiano, Antoine
AU - Bensadoun, René Jean
AU - Auperin, Anne
AU - Poissonnet, Gilles
AU - Bozec, Alexandre
AU - Arriagada, Rodrigo
AU - Temam, Stéphane
AU - Benezery, Karen
AU - Thariat, Juliette
AU - Tao, Yungan
AU - Janot, François
AU - Mamelle, Gérard
AU - Vallicioni, Jacques
AU - Follana, Philippe
AU - Peyrade, Frédéric
AU - Sudaka, Anne
AU - Bourhis, Jean
AU - Dassonville, Olivier
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Purpose: We report the experience of two French cancer centers in the treatment of oral cavity squamous cell carcinoma (SCC) in patients aged ≥80 years. Materials and methods: Two hundred and sixty patients aged ≥80 years with a primary oral cavity SCC were included in this retrospective analysis. Results: Sex ratio was near to 1. Tobacco or alcohol intoxication was the main risk factor for 66% of men and 16% of women and leukoplakia, lichen planus, or oral traumatism for 55% of women and 11% of men (p < 0.0001). Two hundred patients received a loco-regional (LR) treatment with a curative intent (surgery and/or radiotherapy), 29 with a palliative intent and 31 did not receive a LR treatment. Curative treatments were initially planned to be adapted to age in 118 patients (59%). The median disease-specific survival (DSS) was 29 months. In multivariate analysis, the independent prognostic factors for DSS were stage (HR = 0.42 [0.24-0.72]), age (HR = 0.43 [0.24-0.75]) and performance status (HR = 0.50 [0.27-0.95]). The median overall survival (OS) was 14 months. In multivariate analysis, the independent prognostic factors for OS were age (HR = 0.52 [0.35-0.79]), stage (HR = 0.56 [0.38-0.84]), tumor differentiation (HR = 0.60 [0.33-0.93]) and performance status (HR = 0.6 [0.37-0.97]). In patients treated with a curative intent, treatment adapted to age was not associated with a decreased overall survival or disease-specific survival as compared with the standard treatment. However, prophylactic lymph node treatment in stages I-II tumors decreased the rate of nodal recurrence from 38% to 6% (p = 0.01). Conclusion: This study emphasizes the need for prospective evaluation of standard and adapted schedules in elderly patients with oral cavity cancer.
AB - Purpose: We report the experience of two French cancer centers in the treatment of oral cavity squamous cell carcinoma (SCC) in patients aged ≥80 years. Materials and methods: Two hundred and sixty patients aged ≥80 years with a primary oral cavity SCC were included in this retrospective analysis. Results: Sex ratio was near to 1. Tobacco or alcohol intoxication was the main risk factor for 66% of men and 16% of women and leukoplakia, lichen planus, or oral traumatism for 55% of women and 11% of men (p < 0.0001). Two hundred patients received a loco-regional (LR) treatment with a curative intent (surgery and/or radiotherapy), 29 with a palliative intent and 31 did not receive a LR treatment. Curative treatments were initially planned to be adapted to age in 118 patients (59%). The median disease-specific survival (DSS) was 29 months. In multivariate analysis, the independent prognostic factors for DSS were stage (HR = 0.42 [0.24-0.72]), age (HR = 0.43 [0.24-0.75]) and performance status (HR = 0.50 [0.27-0.95]). The median overall survival (OS) was 14 months. In multivariate analysis, the independent prognostic factors for OS were age (HR = 0.52 [0.35-0.79]), stage (HR = 0.56 [0.38-0.84]), tumor differentiation (HR = 0.60 [0.33-0.93]) and performance status (HR = 0.6 [0.37-0.97]). In patients treated with a curative intent, treatment adapted to age was not associated with a decreased overall survival or disease-specific survival as compared with the standard treatment. However, prophylactic lymph node treatment in stages I-II tumors decreased the rate of nodal recurrence from 38% to 6% (p = 0.01). Conclusion: This study emphasizes the need for prospective evaluation of standard and adapted schedules in elderly patients with oral cavity cancer.
KW - Elderly
KW - Geriatric oncology
KW - Oral cavity
KW - Radiotherapy
KW - Squamous cell carcinoma
KW - Surgery
UR - http://www.scopus.com/inward/record.url?scp=70449627824&partnerID=8YFLogxK
U2 - 10.1016/j.radonc.2009.07.015
DO - 10.1016/j.radonc.2009.07.015
M3 - Article
C2 - 19699545
AN - SCOPUS:70449627824
SN - 0167-8140
VL - 93
SP - 516
EP - 523
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 3
ER -