TY - JOUR
T1 - Organization of the mouse and human DC network
AU - Schlitzer, Andreas
AU - Ginhoux, Florent
N1 - Funding Information:
This work was supported by the Singapore Immunology Network (SIgN) core grant. We thank Dr. L. Robinson and Dr. N. McGovern for critical review and editing of the manuscript.
PY - 2014/2/1
Y1 - 2014/2/1
N2 - Dendritic cells (DCs) are the most potent antigen sensing and presenting cells in the body and are able to both initiate and fine-tune complex immune responses on a multitude of levels. In this review, we outline recent advances in our understanding of the organization of the DC network in mice and humans, the functional specialization of the DC subsets that compose these networks, and how this has enabled us to begin to elucidate cross-species parallels. Understanding the inter-relationships between DC populations in both man and mouse will ultimately allow us to exploit our knowledge of DC biology for effective therapeutic strategies.
AB - Dendritic cells (DCs) are the most potent antigen sensing and presenting cells in the body and are able to both initiate and fine-tune complex immune responses on a multitude of levels. In this review, we outline recent advances in our understanding of the organization of the DC network in mice and humans, the functional specialization of the DC subsets that compose these networks, and how this has enabled us to begin to elucidate cross-species parallels. Understanding the inter-relationships between DC populations in both man and mouse will ultimately allow us to exploit our knowledge of DC biology for effective therapeutic strategies.
UR - http://www.scopus.com/inward/record.url?scp=84889687682&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2013.11.002
DO - 10.1016/j.coi.2013.11.002
M3 - Review article
C2 - 24556405
AN - SCOPUS:84889687682
SN - 0952-7915
VL - 26
SP - 90
EP - 99
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 1
ER -