Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells

Miriam Merad; Florent Ginhoux; Matthew Collin

doi:10.1038/nri2455

Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells

Miriam Merad, Florent Ginhoux, Matthew Collin

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658 Citations (Scopus)

Résumé

Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin⁺ DC subsets that are not present in the epidermis, including a subset of DCs that is found in most non-lymphoid tissues. In this Review we describe new developments in the understanding of the biology of LCs and other langerin⁺ DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity.

langue originale	Anglais
Pages (de - à)	935-947
Nombre de pages	13
journal	Nature Reviews Immunology
Volume	8
Numéro de publication	12
Les DOIs	https://doi.org/10.1038/nri2455
état	Publié - 1 déc. 2008
Modification externe	Oui

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10.1038/nri2455

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title = "Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells",

abstract = "Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin+ DC subsets that are not present in the epidermis, including a subset of DCs that is found in most non-lymphoid tissues. In this Review we describe new developments in the understanding of the biology of LCs and other langerin+ DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity.",

author = "Miriam Merad and Florent Ginhoux and Matthew Collin",

note = "Funding Information: We are grateful to R. Steinman, N. Romani, M. Udey and J. Helft for the critical review of the manuscript. We thank P. and E. Kontoyannis for their continuous support of Langerhans and Langerhans-cell histiocytosis research. We apologize to the colleagues whose work we have failed to cite owing to space limitations. M.M. is supported by the National Institutes of Health (grant numbers R01CA1121100 and R01AI0086899). F.G. is supported by the leukemia and the lymphoma research foundation.",

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