TY - JOUR
T1 - Outcome of 449 adult patients with rhabdomyosarcoma
T2 - an observational ambispective nationwide study
AU - Bompas, Emmanuelle
AU - Campion, Loïc
AU - Italiano, Antoine
AU - Le Cesne, Axel
AU - Chevreau, Christine
AU - Isambert, Nicolas
AU - Toulmonde, Maud
AU - Mir, Olivier
AU - Ray-Coquard, Isabelle
AU - Piperno-Neumann, Sophie
AU - Saada-Bouzid, Esma
AU - Rios, Maria
AU - Kurtz, Jean Emmanuel
AU - Delcambre, Corinne
AU - Dubray-Longeras, Pascale
AU - Duffaud, Florence
AU - Karanian, Marie
AU - Le Loarer, François
AU - Soulié, Patrick
AU - Penel, Nicolas
AU - Blay, Jean Yves
N1 - Publisher Copyright:
© 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Five-year overall survival (OS) of localized RMS exceeds 70% in children (<18) but is very poor in adult patients. We analyzed the outcome and prognostic factors (PF) of a national series of adult patients with RMS in a large study. The study population consisted of two different cohorts: a retrospective cohort (157 adult patients treated in 13 reference centers between 05/1981 and 02/2010) and the prospective cohort (292 patients with RMS diagnosed and treated between 01/2010 and 12/2014 in France) included in the NetSarc database. A descriptive analysis of patients’ characteristics and prognostic factors was conducted on both series which were compared. In the retrospective series, histological subtypes were embryonal (E-RMS) for 21% of patients, alveolar (A-RMS) for 35% of patients, and “adult-type” P-RMS (pleomorphic, spindle cell RMS, not otherwise specified) (P) for 44% patients. This distribution significantly differed in the prospective cohort: A-RMS: 18%; E-RMS: 17%; and P-RMS 65%. With a median follow-up of 8.5 years, 5-year OS for localized RMS and advanced RMS (with nodes and/or metastases) was 43% and 5%, respectively, (P < 0.0001), and median OS was 51, 33, and 16 months for E-RMS, A-RMS, and P-RMS, respectively, in the retrospective cohort. The median OS was less than 40 months for the prospective nationwide cohort for the entire population. In a multivariate analysis of the retrospective study, independent prognostic factors for OS were A-RMS, R0 resection, and adjuvant radiotherapy (RT). For localized RMS, age and use of pediatric chemotherapy (CT) regimen are independent prognostic factors. Adult patients with RMS have a poorer overall survival than pediatric patients, and survival varies considerably across histological subtypes.
AB - Five-year overall survival (OS) of localized RMS exceeds 70% in children (<18) but is very poor in adult patients. We analyzed the outcome and prognostic factors (PF) of a national series of adult patients with RMS in a large study. The study population consisted of two different cohorts: a retrospective cohort (157 adult patients treated in 13 reference centers between 05/1981 and 02/2010) and the prospective cohort (292 patients with RMS diagnosed and treated between 01/2010 and 12/2014 in France) included in the NetSarc database. A descriptive analysis of patients’ characteristics and prognostic factors was conducted on both series which were compared. In the retrospective series, histological subtypes were embryonal (E-RMS) for 21% of patients, alveolar (A-RMS) for 35% of patients, and “adult-type” P-RMS (pleomorphic, spindle cell RMS, not otherwise specified) (P) for 44% patients. This distribution significantly differed in the prospective cohort: A-RMS: 18%; E-RMS: 17%; and P-RMS 65%. With a median follow-up of 8.5 years, 5-year OS for localized RMS and advanced RMS (with nodes and/or metastases) was 43% and 5%, respectively, (P < 0.0001), and median OS was 51, 33, and 16 months for E-RMS, A-RMS, and P-RMS, respectively, in the retrospective cohort. The median OS was less than 40 months for the prospective nationwide cohort for the entire population. In a multivariate analysis of the retrospective study, independent prognostic factors for OS were A-RMS, R0 resection, and adjuvant radiotherapy (RT). For localized RMS, age and use of pediatric chemotherapy (CT) regimen are independent prognostic factors. Adult patients with RMS have a poorer overall survival than pediatric patients, and survival varies considerably across histological subtypes.
KW - Adult cancer
KW - pediatric
KW - rhabdomyosarcoma
UR - http://www.scopus.com/inward/record.url?scp=85051564536&partnerID=8YFLogxK
U2 - 10.1002/cam4.1374
DO - 10.1002/cam4.1374
M3 - Review article
C2 - 29956493
AN - SCOPUS:85051564536
SN - 2045-7634
VL - 7
SP - 4023
EP - 4035
JO - Cancer Medicine
JF - Cancer Medicine
IS - 8
ER -