Outcomes in N3 Head and Neck Squamous Cell Carcinoma and Role of Upfront Neck Dissection

Angela Boros; Pierre Blanchard; Arlette Dade; Philippe Gorphe; Ingrid Breuskin; Caroline Even; France Nguyen; Eric Deutsch; François Bidault; François Janot; Stephane Temam; Haitham Mirghani; Yungan Tao

doi:10.1002/lary.28893

Outcomes in N3 Head and Neck Squamous Cell Carcinoma and Role of Upfront Neck Dissection

Angela Boros, Pierre Blanchard, Arlette Dade, Philippe Gorphe, Ingrid Breuskin, Caroline Even, France Nguyen, Eric Deutsch, François Bidault, François Janot, Stephane Temam, Haitham Mirghani, Yungan Tao

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

6 Citations (Scopus)

Résumé

Objectives: We investigated the prognostic factor of N3 head and neck squamous cell carcinoma (HNSCC), including the role of upfront neck dissection (UFND) before radiotherapy (RT). Methods: We retrospectively reviewed the charts of consecutive N3 HNSCC patients treated with curative intent RT. Results: In the study, 323 N3 HNSCC patients were included. Of those, 125 patients (39%) had UFND. Median follow-up was 3.9 years (0–14.8 years). Overall survival (OS) at 5 years was 31.2%, and progression-free survival (PFS) was 26%. In the multivariate analysis, OS was improved in PS 0, T1-2 tumors, patients receiving concurrent chemotherapy, never or former smokers, and UFND. UFND was strongly associated with increased OS (45.7% vs. 21.2%, P <.001), and PFS (P <.001). Regardless of neck node size, UFND improved survival (P =.001 for ≤ 7 cm and P =.004 for > 7 cm). Conclusion: UFND could improve treatment outcomes in N3 HNSCC, especially for non-oropharyngeal cancer, regardless of neck node size. Level of Evidence: 2B Laryngoscope, 131:E844–E850, 2021.

langue originale	Anglais
Pages (de - à)	E846-E850
journal	Laryngoscope
Volume	131
Numéro de publication	3
Les DOIs	https://doi.org/10.1002/lary.28893
état	Publié - 1 mars 2021

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10.1002/lary.28893

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title = "Outcomes in N3 Head and Neck Squamous Cell Carcinoma and Role of Upfront Neck Dissection",

abstract = "Objectives: We investigated the prognostic factor of N3 head and neck squamous cell carcinoma (HNSCC), including the role of upfront neck dissection (UFND) before radiotherapy (RT). Methods: We retrospectively reviewed the charts of consecutive N3 HNSCC patients treated with curative intent RT. Results: In the study, 323 N3 HNSCC patients were included. Of those, 125 patients (39%) had UFND. Median follow-up was 3.9 years (0–14.8 years). Overall survival (OS) at 5 years was 31.2%, and progression-free survival (PFS) was 26%. In the multivariate analysis, OS was improved in PS 0, T1-2 tumors, patients receiving concurrent chemotherapy, never or former smokers, and UFND. UFND was strongly associated with increased OS (45.7% vs. 21.2%, P <.001), and PFS (P <.001). Regardless of neck node size, UFND improved survival (P =.001 for ≤ 7 cm and P =.004 for > 7 cm). Conclusion: UFND could improve treatment outcomes in N3 HNSCC, especially for non-oropharyngeal cancer, regardless of neck node size. Level of Evidence: 2B Laryngoscope, 131:E844–E850, 2021.",

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author = "Angela Boros and Pierre Blanchard and Arlette Dade and Philippe Gorphe and Ingrid Breuskin and Caroline Even and France Nguyen and Eric Deutsch and Fran{\c c}ois Bidault and Fran{\c c}ois Janot and Stephane Temam and Haitham Mirghani and Yungan Tao",

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T1 - Outcomes in N3 Head and Neck Squamous Cell Carcinoma and Role of Upfront Neck Dissection

AU - Boros, Angela

AU - Blanchard, Pierre

AU - Dade, Arlette

AU - Gorphe, Philippe

AU - Breuskin, Ingrid

AU - Even, Caroline

AU - Nguyen, France

AU - Deutsch, Eric

AU - Bidault, François

AU - Janot, François

AU - Temam, Stephane

AU - Mirghani, Haitham

AU - Tao, Yungan

PY - 2021/3/1

Y1 - 2021/3/1

N2 - Objectives: We investigated the prognostic factor of N3 head and neck squamous cell carcinoma (HNSCC), including the role of upfront neck dissection (UFND) before radiotherapy (RT). Methods: We retrospectively reviewed the charts of consecutive N3 HNSCC patients treated with curative intent RT. Results: In the study, 323 N3 HNSCC patients were included. Of those, 125 patients (39%) had UFND. Median follow-up was 3.9 years (0–14.8 years). Overall survival (OS) at 5 years was 31.2%, and progression-free survival (PFS) was 26%. In the multivariate analysis, OS was improved in PS 0, T1-2 tumors, patients receiving concurrent chemotherapy, never or former smokers, and UFND. UFND was strongly associated with increased OS (45.7% vs. 21.2%, P <.001), and PFS (P <.001). Regardless of neck node size, UFND improved survival (P =.001 for ≤ 7 cm and P =.004 for > 7 cm). Conclusion: UFND could improve treatment outcomes in N3 HNSCC, especially for non-oropharyngeal cancer, regardless of neck node size. Level of Evidence: 2B Laryngoscope, 131:E844–E850, 2021.

AB - Objectives: We investigated the prognostic factor of N3 head and neck squamous cell carcinoma (HNSCC), including the role of upfront neck dissection (UFND) before radiotherapy (RT). Methods: We retrospectively reviewed the charts of consecutive N3 HNSCC patients treated with curative intent RT. Results: In the study, 323 N3 HNSCC patients were included. Of those, 125 patients (39%) had UFND. Median follow-up was 3.9 years (0–14.8 years). Overall survival (OS) at 5 years was 31.2%, and progression-free survival (PFS) was 26%. In the multivariate analysis, OS was improved in PS 0, T1-2 tumors, patients receiving concurrent chemotherapy, never or former smokers, and UFND. UFND was strongly associated with increased OS (45.7% vs. 21.2%, P <.001), and PFS (P <.001). Regardless of neck node size, UFND improved survival (P =.001 for ≤ 7 cm and P =.004 for > 7 cm). Conclusion: UFND could improve treatment outcomes in N3 HNSCC, especially for non-oropharyngeal cancer, regardless of neck node size. Level of Evidence: 2B Laryngoscope, 131:E844–E850, 2021.

KW - Head and neck cancer

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