Overcoming the resistance to BRAF inhibitor by the double BRAF and MEK inhibitions in advanced melanoma: A case report

Joseph Kattan, Clarisse Kattan, Fadi Farhat, Tarek Assi

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

4 Citations (Scopus)

Résumé

The advent of BRAF and MEK inhibitors changed the landscape of the management of BRAF mutated melanoma patients. In this article, we report the case of a 51-year-old man with BRAF mutated locally advanced cutaneous melanoma of the head who demonstrated a limited response to initial anti-BRAF monotherapy followed by extensive surgery. Anti-PD1 therapy failed to reverse the disease progression. However, subsequent double inhibition of the BRAF and MEK pathways induced a fast and remarkable tumour response.

langue originaleAnglais
Pages (de - à)1052-1054
Nombre de pages3
journalAnti-Cancer Drugs
Volume30
Numéro de publication10
Les DOIs
étatPublié - 1 nov. 2019
Modification externeOui

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