TY - JOUR
T1 - Papillary Thyroid Cancer—Aggressive Variants and Impact on Management
T2 - A Narrative Review
AU - Coca-Pelaz, Andrés
AU - Shah, Jatin P.
AU - Hernandez-Prera, Juan C.
AU - Ghossein, Ronald A.
AU - Rodrigo, Juan P.
AU - Hartl, Dana M.
AU - Olsen, Kerry D.
AU - Shaha, Ashok R.
AU - Zafereo, Mark
AU - Suarez, Carlos
AU - Nixon, Iain J.
AU - Randolph, Gregory W.
AU - Mäkitie, Antti A.
AU - Kowalski, Luiz P.
AU - Vander Poorten, Vincent
AU - Sanabria, Alvaro
AU - Guntinas-Lichius, Orlando
AU - Simo, Ricard
AU - Zbären, Peter
AU - Angelos, Peter
AU - Khafif, Avi
AU - Rinaldo, Alessandra
AU - Ferlito, Alfio
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Introduction: Aggressive variants of papillary thyroid cancer (PTC) have been described with increasing frequency. These variants include diffuse sclerosing variant, tall cell variant, columnar cell variant, solid variant, and hobnail variant. Methods: We have performed a review of the more aggressive variants of PTC with respect to main characteristics, histological and molecular features, and the consequences that the knowledge of these variants should have in the treatment of the patients. Results: At the present time, we do not know the prognostic value of these aggressive PTC variants. The extent of the surgical treatment and adjuvant therapy necessary should be decided on the basis of the extent of the tumor at presentation and the opinion of experienced clinicians. Conclusion: These aggressive variants should be known by clinicians, to avoid underdiagnosis, and treated according to the latest recommendations in the literature.
AB - Introduction: Aggressive variants of papillary thyroid cancer (PTC) have been described with increasing frequency. These variants include diffuse sclerosing variant, tall cell variant, columnar cell variant, solid variant, and hobnail variant. Methods: We have performed a review of the more aggressive variants of PTC with respect to main characteristics, histological and molecular features, and the consequences that the knowledge of these variants should have in the treatment of the patients. Results: At the present time, we do not know the prognostic value of these aggressive PTC variants. The extent of the surgical treatment and adjuvant therapy necessary should be decided on the basis of the extent of the tumor at presentation and the opinion of experienced clinicians. Conclusion: These aggressive variants should be known by clinicians, to avoid underdiagnosis, and treated according to the latest recommendations in the literature.
KW - Aggressive variants papillary thyroid cancer
KW - Columnar cell variant
KW - Diffuse sclerosis variant
KW - Hobnail variant
KW - Solid variant
KW - Tall cell variant
UR - http://www.scopus.com/inward/record.url?scp=85085879509&partnerID=8YFLogxK
U2 - 10.1007/s12325-020-01391-1
DO - 10.1007/s12325-020-01391-1
M3 - Review article
C2 - 32488657
AN - SCOPUS:85085879509
SN - 0741-238X
VL - 37
SP - 3112
EP - 3128
JO - Advances in Therapy
JF - Advances in Therapy
IS - 7
ER -