Paradoxical cancer cell stimulation by IFNγ drives tumor hyperprogression upon checkpoint blockade immunotherapy

Stephane Champiat; Aurelien Marabelle

doi:10.1016/j.ccell.2023.01.006

Paradoxical cancer cell stimulation by IFNγ drives tumor hyperprogression upon checkpoint blockade immunotherapy

Stephane Champiat, Aurelien Marabelle

Résultats de recherche: Contribution à un journal › !!Comment/debate

5 Citations (Scopus)

Résumé

Hyperprogression is a paradoxical cancer acceleration observed in a minority of patients upon immunotherapy. In this issue of Cancer Cell, Li et al demonstrate that hyperprogressive tumors upregulate the Wnt/β-catenin pathway. This activation was subsequent to an oncogenic FGF2-mediated autocrine loop generated by the IFNγ released by CD8⁺ T cells upon PD-1/PD-L1 blockade.

langue originale	Anglais
Pages (de - à)	229-231
Nombre de pages	3
journal	Cancer Cell
Volume	41
Numéro de publication	2
Les DOIs	https://doi.org/10.1016/j.ccell.2023.01.006
état	Publié - 13 févr. 2023

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10.1016/j.ccell.2023.01.006

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title = "Paradoxical cancer cell stimulation by IFNγ drives tumor hyperprogression upon checkpoint blockade immunotherapy",

abstract = "Hyperprogression is a paradoxical cancer acceleration observed in a minority of patients upon immunotherapy. In this issue of Cancer Cell, Li et al demonstrate that hyperprogressive tumors upregulate the Wnt/β-catenin pathway. This activation was subsequent to an oncogenic FGF2-mediated autocrine loop generated by the IFNγ released by CD8+ T cells upon PD-1/PD-L1 blockade.",

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