Paragangliomes malins héréditaires : problèmes liés à la prise en charge des formes non sécrétantes

S. Bonnet; X. Durand; O. Baton; A. P. Gimenez-Roqueplo; E. Baudin; J. Visset; J. P. Algayres; B. Baranger

doi:10.1016/j.anchir.2006.05.004

Paragangliomes malins héréditaires : problèmes liés à la prise en charge des formes non sécrétantes

S. Bonnet, X. Durand, O. Baton, A. P. Gimenez-Roqueplo, E. Baudin, J. Visset, J. P. Algayres, B. Baranger

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

8 Citations (Scopus)

Résumé

Non-functional paraganglioma have not clinical or biological characteristics, so that the diagnostic is most of the time delayed and made on the occasion of advanced abdominal tumor or symptomatic metastasis management. Hereditary forms, notably those with SDHB mutation, seem to have a poor prognosis. On the other hand, and on the oposite to sporadic forms, they are the only ones to benefit from genetic testing which make possible, if positive, an earlier diagnostic, before apparition of symptoms, recurrence or metastasis. We report a case of non-functional malignant hereditary paraganglioma diagnosed belatedly and we will consider management problems raised by non-functional forms.

Titre traduit de la contribution	Malignant hereditary paraganglioma: problems raised by non-functional forms management
langue originale	Français
Pages (de - à)	626-630
Nombre de pages	5
journal	Annales de Chirurgie
Volume	131
Numéro de publication	10
Les DOIs	https://doi.org/10.1016/j.anchir.2006.05.004
état	Publié - 1 déc. 2006

mots-clés

Genetic testing
Malignant hereditary paraganglioma
Metastasis
Non-functional paraganglioma
SDHB mutation

Accès au document

10.1016/j.anchir.2006.05.004

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Contient cette citation

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title = "Paragangliomes malins h{\'e}r{\'e}ditaires : probl{\`e}mes li{\'e}s {\`a} la prise en charge des formes non s{\'e}cr{\'e}tantes",

abstract = "Non-functional paraganglioma have not clinical or biological characteristics, so that the diagnostic is most of the time delayed and made on the occasion of advanced abdominal tumor or symptomatic metastasis management. Hereditary forms, notably those with SDHB mutation, seem to have a poor prognosis. On the other hand, and on the oposite to sporadic forms, they are the only ones to benefit from genetic testing which make possible, if positive, an earlier diagnostic, before apparition of symptoms, recurrence or metastasis. We report a case of non-functional malignant hereditary paraganglioma diagnosed belatedly and we will consider management problems raised by non-functional forms.",

keywords = "Genetic testing, Malignant hereditary paraganglioma, Metastasis, Non-functional paraganglioma, SDHB mutation",

author = "S. Bonnet and X. Durand and O. Baton and Gimenez-Roqueplo, {A. P.} and E. Baudin and J. Visset and Algayres, {J. P.} and B. Baranger",

year = "2006",

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doi = "10.1016/j.anchir.2006.05.004",

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T1 - Paragangliomes malins héréditaires

T2 - problèmes liés à la prise en charge des formes non sécrétantes

AU - Bonnet, S.

AU - Durand, X.

AU - Baton, O.

AU - Gimenez-Roqueplo, A. P.

AU - Baudin, E.

AU - Visset, J.

AU - Algayres, J. P.

AU - Baranger, B.

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Non-functional paraganglioma have not clinical or biological characteristics, so that the diagnostic is most of the time delayed and made on the occasion of advanced abdominal tumor or symptomatic metastasis management. Hereditary forms, notably those with SDHB mutation, seem to have a poor prognosis. On the other hand, and on the oposite to sporadic forms, they are the only ones to benefit from genetic testing which make possible, if positive, an earlier diagnostic, before apparition of symptoms, recurrence or metastasis. We report a case of non-functional malignant hereditary paraganglioma diagnosed belatedly and we will consider management problems raised by non-functional forms.

AB - Non-functional paraganglioma have not clinical or biological characteristics, so that the diagnostic is most of the time delayed and made on the occasion of advanced abdominal tumor or symptomatic metastasis management. Hereditary forms, notably those with SDHB mutation, seem to have a poor prognosis. On the other hand, and on the oposite to sporadic forms, they are the only ones to benefit from genetic testing which make possible, if positive, an earlier diagnostic, before apparition of symptoms, recurrence or metastasis. We report a case of non-functional malignant hereditary paraganglioma diagnosed belatedly and we will consider management problems raised by non-functional forms.

KW - Genetic testing

KW - Malignant hereditary paraganglioma

KW - Metastasis

KW - Non-functional paraganglioma

KW - SDHB mutation

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DO - 10.1016/j.anchir.2006.05.004

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