PARP1 inhibition elicits immune responses against non-small cell lung cancer

Pan Juncheng; Antoine Lafarge; Guido Kroemer; Maria Castedo

doi:10.1080/2162402X.2022.2111915

PARP1 inhibition elicits immune responses against non-small cell lung cancer

Pan Juncheng, Antoine Lafarge, Guido Kroemer, Maria Castedo

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

3 Citations (Scopus)

Résumé

High levels of intracellular poly(ADP-ribose) (PAR) resulting from an elevated activity of PAR polymerase-1 (PARP1) correlate with poor infiltration of non-small cell lung cancers by cytotoxic T lymphocytes and dismal patient prognosis. Preclinical experimentation now demonstrates that PARP1 inhibition in cancer cells mediates strong immunostimulatory effects.

langue originale	Anglais
Numéro d'article	2111915
journal	OncoImmunology
Volume	11
Numéro de publication	1
Les DOIs	https://doi.org/10.1080/2162402X.2022.2111915
état	Publié - 1 janv. 2022

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10.1080/2162402X.2022.2111915

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title = "PARP1 inhibition elicits immune responses against non-small cell lung cancer",

abstract = "High levels of intracellular poly(ADP-ribose) (PAR) resulting from an elevated activity of PAR polymerase-1 (PARP1) correlate with poor infiltration of non-small cell lung cancers by cytotoxic T lymphocytes and dismal patient prognosis. Preclinical experimentation now demonstrates that PARP1 inhibition in cancer cells mediates strong immunostimulatory effects.",

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author = "Pan Juncheng and Antoine Lafarge and Guido Kroemer and Maria Castedo",

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KW - immune escape

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