Pathogenic hyperactivation of mTORC1 by cytoplasmic EP300 in Hutchinson-Gilford progeria syndrome

Lucille Ferret, Guido Kroemer, Mojgan Djavaheri-Mergny

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    Résumé

    In a recent issue in Nature Cell Biology, Sung Min Son et al. unveil a novel layer in the regulation of the mTORC1/autophagy axis by EP300 which can undergo nucleocytoplasmic shuttling in response to alterations in nutrient availability. The study highlights that, in Hutchinson-Gilford progeria syndrome, overabundant cytoplasmic EP300 results in mTORC1 hyperactivation and impaired autophagy, potentially contributing to premature and accelerated aging.

    langue originaleAnglais
    Pages (de - à)51-55
    Nombre de pages5
    journalCell Stress
    Volume8
    Numéro de publication1
    Les DOIs
    étatPublié - 1 janv. 2024

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