Résumé
In a recent issue in Nature Cell Biology, Sung Min Son et al. unveil a novel layer in the regulation of the mTORC1/autophagy axis by EP300 which can undergo nucleocytoplasmic shuttling in response to alterations in nutrient availability. The study highlights that, in Hutchinson-Gilford progeria syndrome, overabundant cytoplasmic EP300 results in mTORC1 hyperactivation and impaired autophagy, potentially contributing to premature and accelerated aging.
langue originale | Anglais |
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Pages (de - à) | 51-55 |
Nombre de pages | 5 |
journal | Cell Stress |
Volume | 8 |
Numéro de publication | 1 |
Les DOIs | |
état | Publié - 1 janv. 2024 |