Pathophysiology of Cancer Cell Death

Lorenzo Galluzzi; Andreas Linkermann; Oliver Kepp; Guido Kroemer

doi:10.1016/B978-0-323-47674-4.00005-0

Pathophysiology of Cancer Cell Death

Lorenzo Galluzzi, Andreas Linkermann, Oliver Kepp, Guido Kroemer

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2 Citations (Scopus)

Résumé

Malignant transformation, tumor progression and resistance to cancer therapy often occur in the context of disabled cell death signaling. Here we describe the major mechanisms of cell death regulation in mammalian cells and discuss the pathophysiologic and therapeutic implications of their deregulation in the course of oncogenesis.

langue originale	Anglais
titre	Abeloff’s Clinical Oncology
Editeur	Elsevier
Pages	74-83.e4
ISBN (Electronique)	9780323476744
Les DOIs	https://doi.org/10.1016/B978-0-323-47674-4.00005-0
état	Publié - 1 janv. 2019
Modification externe	Oui

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10.1016/B978-0-323-47674-4.00005-0

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title = "Pathophysiology of Cancer Cell Death",

abstract = "Malignant transformation, tumor progression and resistance to cancer therapy often occur in the context of disabled cell death signaling. Here we describe the major mechanisms of cell death regulation in mammalian cells and discuss the pathophysiologic and therapeutic implications of their deregulation in the course of oncogenesis.",

keywords = "Apoptosis, Bcl-2 proteins, Caspases, MPT-driven regulated necrosis, NF-κB, Necroptosis, Pyroptosis",

author = "Lorenzo Galluzzi and Andreas Linkermann and Oliver Kepp and Guido Kroemer",

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year = "2019",

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AU - Galluzzi, Lorenzo

AU - Linkermann, Andreas

AU - Kepp, Oliver

AU - Kroemer, Guido

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N2 - Malignant transformation, tumor progression and resistance to cancer therapy often occur in the context of disabled cell death signaling. Here we describe the major mechanisms of cell death regulation in mammalian cells and discuss the pathophysiologic and therapeutic implications of their deregulation in the course of oncogenesis.

AB - Malignant transformation, tumor progression and resistance to cancer therapy often occur in the context of disabled cell death signaling. Here we describe the major mechanisms of cell death regulation in mammalian cells and discuss the pathophysiologic and therapeutic implications of their deregulation in the course of oncogenesis.

KW - Apoptosis

KW - Bcl-2 proteins

KW - Caspases

KW - MPT-driven regulated necrosis

KW - NF-κB

KW - Necroptosis

KW - Pyroptosis

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BT - Abeloff’s Clinical Oncology

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