TY - JOUR
T1 - Patient-reported outcomes with lanreotide Autogel/Depot for carcinoid syndrome
T2 - An international observational study
AU - on behalf of the SYMNET study group
AU - Ruszniewski, Philippe
AU - Valle, Juan W.
AU - Lombard-Bohas, Catherine
AU - Cuthbertson, Daniel J.
AU - Perros, Petros
AU - Holubec, Luboš
AU - Delle Fave, Gianfranco
AU - Smith, Denis
AU - Niccoli, Patricia
AU - Maisonobe, Pascal
AU - Atlan, Philippe
AU - Caplin, Martyn E.
N1 - Publisher Copyright:
© 2016 The Authors.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Background: Lanreotide Autogel/Depot effectively controls symptoms in patients with carcinoid syndrome associated with neuroendocrine tumours. Data on patient-reported outcomes are sparse. Aim: To evaluate the effect of lanreotide on patient-reported outcomes (PROs) with carcinoid syndrome. Methods: This was an international, open-label, observational study of adults with neuroendocrine tumours and history of diarrhoea, receiving lanreotide for >3 months for relief of carcinoid syndrome symptoms. The primary PRO measure was satisfaction with diarrhoea control. Secondary PRO measures included severity, change in symptoms and impact on daily life of diarrhoea; and patient satisfaction with flushing control. Results: Of 273 patients enrolled, 76% were 'completely' or 'rather' satisfied with diarrhoea control; 79% reported improvement in diarrhoea with lanreotide. The proportion of patients with 'mild', 'minimal', or 'no diarrhoea' increased from 33% before treatment to 75% during treatment; 75% were unconcerned about the impact of diarrhoea on daily life. Satisfaction with flushing control amongst patients with significant flushing at treatment initiation was 73%. Conclusions: Lanreotide treatment was associated with improvements in symptoms as well as a range of PROs in patients with neuroendocrine tumours and carcinoid syndrome (ClinicalTrials.gov: NCT01234168).
AB - Background: Lanreotide Autogel/Depot effectively controls symptoms in patients with carcinoid syndrome associated with neuroendocrine tumours. Data on patient-reported outcomes are sparse. Aim: To evaluate the effect of lanreotide on patient-reported outcomes (PROs) with carcinoid syndrome. Methods: This was an international, open-label, observational study of adults with neuroendocrine tumours and history of diarrhoea, receiving lanreotide for >3 months for relief of carcinoid syndrome symptoms. The primary PRO measure was satisfaction with diarrhoea control. Secondary PRO measures included severity, change in symptoms and impact on daily life of diarrhoea; and patient satisfaction with flushing control. Results: Of 273 patients enrolled, 76% were 'completely' or 'rather' satisfied with diarrhoea control; 79% reported improvement in diarrhoea with lanreotide. The proportion of patients with 'mild', 'minimal', or 'no diarrhoea' increased from 33% before treatment to 75% during treatment; 75% were unconcerned about the impact of diarrhoea on daily life. Satisfaction with flushing control amongst patients with significant flushing at treatment initiation was 73%. Conclusions: Lanreotide treatment was associated with improvements in symptoms as well as a range of PROs in patients with neuroendocrine tumours and carcinoid syndrome (ClinicalTrials.gov: NCT01234168).
KW - Diarrhoea
KW - Neuroendocrine tumour
UR - http://www.scopus.com/inward/record.url?scp=84963541109&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2015.12.013
DO - 10.1016/j.dld.2015.12.013
M3 - Article
C2 - 26917486
AN - SCOPUS:84963541109
SN - 1590-8658
VL - 48
SP - 552
EP - 558
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 5
ER -