TY - JOUR
T1 - Pediatric salivary gland carcinomas
T2 - Diagnostic and therapeutic management
AU - for the Pediatric French Rare Tumor Group
AU - Rebours, Céleste
AU - Couloigner, Vincent
AU - Galmiche, Louise
AU - Casiraghi, Odile
AU - Badoual, Cécile
AU - Boudjemaa, Sabah
AU - Chauvin, Anthony
AU - Elmaleh, Monique
AU - Fresneau, Brice
AU - Fasola, Sylvie
AU - Garabédian, Erea Noël
AU - Van Den Abeele, Thierry
AU - Orbach, Daniel
N1 - Publisher Copyright:
© 2016 The American Laryngological, Rhinological and Otological Society, Inc.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objectives/Hypothesis: To analyze clinical presentations, treatment modalities, and evolution of pediatric cases of salivary gland carcinomas to standardize care for these rare diseases. Study Design: Multicentric, retrospective study. Methods: We included in this retrospective study all children and adolescents (aged ≤18 years) treated from 1992 to 2012 in six pediatric centers in Paris, France. Pathological tumor specimens of these cases were reviewed. Results: Forty-three children were included (sex ratio male/female = 19/24, median age = 13 years). The parotid gland was the most common (37 cases) location for tumors. Histological subtypes were mucoepidermoid carcinomas (n = 20), acinic cell carcinomas (n = 14), and other (n = 9). Initial fine-needle aspiration was performed in 15 cases (33%), and was concordant to final diagnosis in three cases (20%). Primary surgery was performed in 42 patients, leading to a complete microscopic resection in 80%. Associated lymph node dissection was performed in 28 patients (homolateral: 27, bilateral: 1) and showed lymph node metastases in only two patients. One patient had distant metastases. Adjuvant irradiation was delivered to 11 patients (median: 60 Gy; range: 50–65) and chemotherapy in five cases. After a median follow-up of 5 years, six tumors relapsed, but no deaths occurred. Conclusions: Childhood salivary gland carcinomas have a good prognosis despite possible recurrences. Treatment is mainly based on surgery, with simultaneous node dissection in cases of clinical or radiologic node enlargement. Radiation therapy seems to be restricted to inoperable high-grade tumors or after recurrence. Level of Evidence: 4 Laryngoscope, 127:140–147, 2017.
AB - Objectives/Hypothesis: To analyze clinical presentations, treatment modalities, and evolution of pediatric cases of salivary gland carcinomas to standardize care for these rare diseases. Study Design: Multicentric, retrospective study. Methods: We included in this retrospective study all children and adolescents (aged ≤18 years) treated from 1992 to 2012 in six pediatric centers in Paris, France. Pathological tumor specimens of these cases were reviewed. Results: Forty-three children were included (sex ratio male/female = 19/24, median age = 13 years). The parotid gland was the most common (37 cases) location for tumors. Histological subtypes were mucoepidermoid carcinomas (n = 20), acinic cell carcinomas (n = 14), and other (n = 9). Initial fine-needle aspiration was performed in 15 cases (33%), and was concordant to final diagnosis in three cases (20%). Primary surgery was performed in 42 patients, leading to a complete microscopic resection in 80%. Associated lymph node dissection was performed in 28 patients (homolateral: 27, bilateral: 1) and showed lymph node metastases in only two patients. One patient had distant metastases. Adjuvant irradiation was delivered to 11 patients (median: 60 Gy; range: 50–65) and chemotherapy in five cases. After a median follow-up of 5 years, six tumors relapsed, but no deaths occurred. Conclusions: Childhood salivary gland carcinomas have a good prognosis despite possible recurrences. Treatment is mainly based on surgery, with simultaneous node dissection in cases of clinical or radiologic node enlargement. Radiation therapy seems to be restricted to inoperable high-grade tumors or after recurrence. Level of Evidence: 4 Laryngoscope, 127:140–147, 2017.
KW - childhood rare tumors
KW - retrospective study
KW - Salivary gland carcinomas
UR - http://www.scopus.com/inward/record.url?scp=84994314552&partnerID=8YFLogxK
U2 - 10.1002/lary.26204
DO - 10.1002/lary.26204
M3 - Article
C2 - 27497071
AN - SCOPUS:84994314552
SN - 0023-852X
VL - 127
SP - 140
EP - 147
JO - Laryngoscope
JF - Laryngoscope
IS - 1
ER -