Phénotypes et fonctions des lymphocytes T en pathologie tumorale

Cécile Badoual; Benoît Vingert; Nour Agueznay; Olivier Adotevi; Nacilla Haicheur; Thierry Molina; Patrick Bruneval; Wolf H. Fridman; Eric Tartour

doi:10.1016/S0242-6498(05)80112-9

Phénotypes et fonctions des lymphocytes T en pathologie tumorale

Cécile Badoual, Benoît Vingert, Nour Agueznay, Olivier Adotevi, Nacilla Haicheur, Thierry Molina, Patrick Bruneval, Wolf H. Fridman, Eric Tartour

Résultats de recherche: Contribution à un journal › Brève enquête › Revue par des pairs

1 Citation (Scopus)

Résumé

In preclinical tumor model and in human cancer, tumor antigen specific T lymphocytes play a key role in the control of tumor development. Nevertheless in numerous cases, the infiltrating tumor T cells do not seem to influence the clinical progression of the tumor. A better phenotypic and functional characterization of T cells in close contact with tumor associated with a comprehensive analysis of tumor evasion mechanism to the host response should lead to an optimization of cancer immunotherapy protocols.

Titre traduit de la contribution	Phenotypic and functional analysis of T lymphocytes in cancer patients
langue originale	Français
Pages (de - à)	211-219
Nombre de pages	9
journal	Annales de Pathologie
Volume	25
Numéro de publication	3
Les DOIs	https://doi.org/10.1016/S0242-6498(05)80112-9
état	Publié - 1 janv. 2005

mots-clés

Cytokine
Prognosis
T lymphocyte
Tumor
Tumor antigen

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10.1016/S0242-6498(05)80112-9

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abstract = "In preclinical tumor model and in human cancer, tumor antigen specific T lymphocytes play a key role in the control of tumor development. Nevertheless in numerous cases, the infiltrating tumor T cells do not seem to influence the clinical progression of the tumor. A better phenotypic and functional characterization of T cells in close contact with tumor associated with a comprehensive analysis of tumor evasion mechanism to the host response should lead to an optimization of cancer immunotherapy protocols.",

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AU - Badoual, Cécile

AU - Vingert, Benoît

AU - Agueznay, Nour

AU - Adotevi, Olivier

AU - Haicheur, Nacilla

AU - Molina, Thierry

AU - Bruneval, Patrick

AU - Fridman, Wolf H.

AU - Tartour, Eric

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N2 - In preclinical tumor model and in human cancer, tumor antigen specific T lymphocytes play a key role in the control of tumor development. Nevertheless in numerous cases, the infiltrating tumor T cells do not seem to influence the clinical progression of the tumor. A better phenotypic and functional characterization of T cells in close contact with tumor associated with a comprehensive analysis of tumor evasion mechanism to the host response should lead to an optimization of cancer immunotherapy protocols.

AB - In preclinical tumor model and in human cancer, tumor antigen specific T lymphocytes play a key role in the control of tumor development. Nevertheless in numerous cases, the infiltrating tumor T cells do not seem to influence the clinical progression of the tumor. A better phenotypic and functional characterization of T cells in close contact with tumor associated with a comprehensive analysis of tumor evasion mechanism to the host response should lead to an optimization of cancer immunotherapy protocols.

KW - Cytokine

KW - Prognosis

KW - T lymphocyte

KW - Tumor

KW - Tumor antigen

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