Pharmacogenetics and application in pediatrics

Virginia Neyro, Evelyne Jacqz-Aigrain, Tiphaine Adam de Beaumais

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    5 Citations (Scopus)

    Résumé

    Identification of markers involved in drug disposition is crucial for drugs with a narrow therapeutic index. Individual genomic differences can affect the pharmacology of some drugs and participate to inter-individual variability in drug response. Pharmacogenetics is a useful tool in clinical practice for dosage adjustment and to limit drug toxicities. In pediatrics, physiological changes can also influence the disposition of drugs in infants, children and adolescents. The importance of ontogeny translates into different responses to the same drug in children and adults. Thus, interactions between the maturation of metabolism enzymes or transporters and genetics have a major impact on drug exposure leading to age-specific dosage requirements. This review aims to describe implementation of pharmacogenetics in personalized medicine and specifies pediatric characteristics with ethical considerations.

    langue originaleAnglais
    Pages (de - à)157-163
    Nombre de pages7
    journalTherapie
    Volume73
    Numéro de publication2
    Les DOIs
    étatPublié - 1 avr. 2018

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