TY - JOUR
T1 - Pharmacogenetics and application in pediatrics
AU - Neyro, Virginia
AU - Jacqz-Aigrain, Evelyne
AU - Adam de Beaumais, Tiphaine
N1 - Publisher Copyright:
© 2018 Société française de pharmacologie et de thérapeutique
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Identification of markers involved in drug disposition is crucial for drugs with a narrow therapeutic index. Individual genomic differences can affect the pharmacology of some drugs and participate to inter-individual variability in drug response. Pharmacogenetics is a useful tool in clinical practice for dosage adjustment and to limit drug toxicities. In pediatrics, physiological changes can also influence the disposition of drugs in infants, children and adolescents. The importance of ontogeny translates into different responses to the same drug in children and adults. Thus, interactions between the maturation of metabolism enzymes or transporters and genetics have a major impact on drug exposure leading to age-specific dosage requirements. This review aims to describe implementation of pharmacogenetics in personalized medicine and specifies pediatric characteristics with ethical considerations.
AB - Identification of markers involved in drug disposition is crucial for drugs with a narrow therapeutic index. Individual genomic differences can affect the pharmacology of some drugs and participate to inter-individual variability in drug response. Pharmacogenetics is a useful tool in clinical practice for dosage adjustment and to limit drug toxicities. In pediatrics, physiological changes can also influence the disposition of drugs in infants, children and adolescents. The importance of ontogeny translates into different responses to the same drug in children and adults. Thus, interactions between the maturation of metabolism enzymes or transporters and genetics have a major impact on drug exposure leading to age-specific dosage requirements. This review aims to describe implementation of pharmacogenetics in personalized medicine and specifies pediatric characteristics with ethical considerations.
KW - Genetics
KW - Pediatrics
KW - Pharmacology
UR - http://www.scopus.com/inward/record.url?scp=85043227683&partnerID=8YFLogxK
U2 - 10.1016/j.therap.2017.11.010
DO - 10.1016/j.therap.2017.11.010
M3 - Article
C2 - 29530313
AN - SCOPUS:85043227683
SN - 0040-5957
VL - 73
SP - 157
EP - 163
JO - Therapie
JF - Therapie
IS - 2
ER -