Pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection

Toshio Hisatomi; Tatsuro Ishibashi; Joan W. Miller; Guido Kroemer

doi:10.1016/j.expneurol.2009.03.007

Pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection

Toshio Hisatomi, Tatsuro Ishibashi, Joan W. Miller, Guido Kroemer

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

24 Citations (Scopus)

Résumé

Recent data have provided important clues about the molecular mechanisms underlying certain neurodegenerative diseases. Most cell death in vertebrates proceeds via the mitochondrial pathway of apoptosis. Mitochondria contain proapoptotic factors such as cytochrome c and AIF in their intermembrane space. Furthermore, mitochondrial membrane permeabilization (MMP) is a critical event during apoptosis, representing the "point of no return" of the lethal process. Modern medicine is developing an increasing number of drugs for neurodegenerative disease, but no neuroprotective treatment has yet been established. While current treatments temporarily alleviate symptoms, they do not halt disease progression. This paper briefly reviews the pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection.

langue originale	Anglais
Pages (de - à)	347-352
Nombre de pages	6
journal	Experimental Neurology
Volume	218
Numéro de publication	2
Les DOIs	https://doi.org/10.1016/j.expneurol.2009.03.007
état	Publié - 1 août 2009

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10.1016/j.expneurol.2009.03.007

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@article{f8882b21a0b349ec868b12082a882cc8,

title = "Pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection",

abstract = "Recent data have provided important clues about the molecular mechanisms underlying certain neurodegenerative diseases. Most cell death in vertebrates proceeds via the mitochondrial pathway of apoptosis. Mitochondria contain proapoptotic factors such as cytochrome c and AIF in their intermembrane space. Furthermore, mitochondrial membrane permeabilization (MMP) is a critical event during apoptosis, representing the {"}point of no return{"} of the lethal process. Modern medicine is developing an increasing number of drugs for neurodegenerative disease, but no neuroprotective treatment has yet been established. While current treatments temporarily alleviate symptoms, they do not halt disease progression. This paper briefly reviews the pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection.",

keywords = "AIF, Apaf-1, Apoptosis, Caspase, Cytochrome c, Mitochondria membrane permeabilization, Retina",

author = "Toshio Hisatomi and Tatsuro Ishibashi and Miller, {Joan W.} and Guido Kroemer",

note = "Funding Information: GK is supported by the Ligue Nationale contre le Cancer (Equipe labellis{\'e}e), European Commission (Active p53, Apo-Sys, RIGHT, TransDeath, ChemoRes, DeathTrain), Canc{\'e}rop{\^o}le Ile-de-France, Fondation de France, and Fondation pour la Recherche M{\'e}dicale.",

year = "2009",

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doi = "10.1016/j.expneurol.2009.03.007",

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T1 - Pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection

AU - Hisatomi, Toshio

AU - Ishibashi, Tatsuro

AU - Miller, Joan W.

AU - Kroemer, Guido

N1 - Funding Information: GK is supported by the Ligue Nationale contre le Cancer (Equipe labellisée), European Commission (Active p53, Apo-Sys, RIGHT, TransDeath, ChemoRes, DeathTrain), Cancéropôle Ile-de-France, Fondation de France, and Fondation pour la Recherche Médicale.

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Recent data have provided important clues about the molecular mechanisms underlying certain neurodegenerative diseases. Most cell death in vertebrates proceeds via the mitochondrial pathway of apoptosis. Mitochondria contain proapoptotic factors such as cytochrome c and AIF in their intermembrane space. Furthermore, mitochondrial membrane permeabilization (MMP) is a critical event during apoptosis, representing the "point of no return" of the lethal process. Modern medicine is developing an increasing number of drugs for neurodegenerative disease, but no neuroprotective treatment has yet been established. While current treatments temporarily alleviate symptoms, they do not halt disease progression. This paper briefly reviews the pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection.

AB - Recent data have provided important clues about the molecular mechanisms underlying certain neurodegenerative diseases. Most cell death in vertebrates proceeds via the mitochondrial pathway of apoptosis. Mitochondria contain proapoptotic factors such as cytochrome c and AIF in their intermembrane space. Furthermore, mitochondrial membrane permeabilization (MMP) is a critical event during apoptosis, representing the "point of no return" of the lethal process. Modern medicine is developing an increasing number of drugs for neurodegenerative disease, but no neuroprotective treatment has yet been established. While current treatments temporarily alleviate symptoms, they do not halt disease progression. This paper briefly reviews the pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection.

KW - AIF

KW - Apaf-1

KW - Apoptosis

KW - Caspase

KW - Cytochrome c

KW - Mitochondria membrane permeabilization

KW - Retina

UR - http://www.scopus.com/inward/record.url?scp=67649793306&partnerID=8YFLogxK

U2 - 10.1016/j.expneurol.2009.03.007

DO - 10.1016/j.expneurol.2009.03.007

M3 - Review article

C2 - 19303007

AN - SCOPUS:67649793306

SN - 0014-4886

VL - 218

SP - 347

EP - 352

JO - Experimental Neurology

JF - Experimental Neurology

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ER -