Pharmacological inhibition of programmed lymphocyte death

Guido Kroemer; Carlos Martínez-A

doi:10.1016/0167-5699(94)90249-6

Pharmacological inhibition of programmed lymphocyte death

Guido Kroemer, Carlos Martínez-A

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

72 Citations (Scopus)

Résumé

Programmed cell death (PCD) is a necessary process that helps to regulate the lifespan of lymphocytes and maintain the compartmental balance of lymphoid organs. In addition, PCD is required for the generation and maintenance of self-tolerance. Strategies that inhibit PCD cause profound alternations in the (patho)physiology of the immune system. Here, Guido Kroemer and Carlos Martínez-A. discuss the multiplicity of PCD-inducing pathways, which have been revealed through the use of PCD-inhibitory agents, and analyse the levels at which these agents act.

langue originale	Anglais
Pages (de - à)	235-242
Nombre de pages	8
journal	Immunology Today
Volume	15
Numéro de publication	5
Les DOIs	https://doi.org/10.1016/0167-5699(94)90249-6
état	Publié - 1 janv. 1994
Modification externe	Oui

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10.1016/0167-5699(94)90249-6

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title = "Pharmacological inhibition of programmed lymphocyte death",

abstract = "Programmed cell death (PCD) is a necessary process that helps to regulate the lifespan of lymphocytes and maintain the compartmental balance of lymphoid organs. In addition, PCD is required for the generation and maintenance of self-tolerance. Strategies that inhibit PCD cause profound alternations in the (patho)physiology of the immune system. Here, Guido Kroemer and Carlos Mart{\'i}nez-A. discuss the multiplicity of PCD-inducing pathways, which have been revealed through the use of PCD-inhibitory agents, and analyse the levels at which these agents act.",

author = "Guido Kroemer and Carlos Mart{\'i}nez-A",

note = "Funding Information: We thank J.A. Gonzalo and A. Gonz~lez-Garcia for allowing us to quote their unpublished work. This work was supported by the ARC, FNRM, EC, CICyT and Kabi Pharmacia.",

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AU - Kroemer, Guido

AU - Martínez-A, Carlos

N1 - Funding Information: We thank J.A. Gonzalo and A. Gonz~lez-Garcia for allowing us to quote their unpublished work. This work was supported by the ARC, FNRM, EC, CICyT and Kabi Pharmacia.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Programmed cell death (PCD) is a necessary process that helps to regulate the lifespan of lymphocytes and maintain the compartmental balance of lymphoid organs. In addition, PCD is required for the generation and maintenance of self-tolerance. Strategies that inhibit PCD cause profound alternations in the (patho)physiology of the immune system. Here, Guido Kroemer and Carlos Martínez-A. discuss the multiplicity of PCD-inducing pathways, which have been revealed through the use of PCD-inhibitory agents, and analyse the levels at which these agents act.

AB - Programmed cell death (PCD) is a necessary process that helps to regulate the lifespan of lymphocytes and maintain the compartmental balance of lymphoid organs. In addition, PCD is required for the generation and maintenance of self-tolerance. Strategies that inhibit PCD cause profound alternations in the (patho)physiology of the immune system. Here, Guido Kroemer and Carlos Martínez-A. discuss the multiplicity of PCD-inducing pathways, which have been revealed through the use of PCD-inhibitory agents, and analyse the levels at which these agents act.

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