TY - JOUR
T1 - Pioneer translation products as an alternative source for MHC-I antigenic peptides
AU - Apcher, Sebastien
AU - Daskalogianni, Chrysoula
AU - Fåhraeus, Robin
N1 - Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2015/3/26
Y1 - 2015/3/26
N2 - The notion that alternative peptide substrates can be processed and presented to the MHC class I pathway has opened for new aspects on how the immune system detects infected or damaged cells. Recent works show that antigenic peptides are derived from intron sequences in pre-mRNAs target for the nonsense-mediated degradation pathway. Introns are spliced out co-transcriptionally suggesting that such pioneer translation products (PTPs) are synthesized on the nascent RNAs in the nuclear compartment to ensure that the first peptides to emerge from an mRNA are destined for the class I pathway. This illustrates an independent translation event during mRNA maturation that give rise to specific peptide products with a specific function in the immune system. The characterization of the translation apparatus responsible for PTP synthesis will pave the way for understanding how PTP production is regulated in different tissues under different conditions and will help designing new vaccine strategies.
AB - The notion that alternative peptide substrates can be processed and presented to the MHC class I pathway has opened for new aspects on how the immune system detects infected or damaged cells. Recent works show that antigenic peptides are derived from intron sequences in pre-mRNAs target for the nonsense-mediated degradation pathway. Introns are spliced out co-transcriptionally suggesting that such pioneer translation products (PTPs) are synthesized on the nascent RNAs in the nuclear compartment to ensure that the first peptides to emerge from an mRNA are destined for the class I pathway. This illustrates an independent translation event during mRNA maturation that give rise to specific peptide products with a specific function in the immune system. The characterization of the translation apparatus responsible for PTP synthesis will pave the way for understanding how PTP production is regulated in different tissues under different conditions and will help designing new vaccine strategies.
KW - Alternative mRNA translation products
KW - MHC class I antigen presentation
UR - http://www.scopus.com/inward/record.url?scp=84955632443&partnerID=8YFLogxK
U2 - 10.1016/j.molimm.2015.04.019
DO - 10.1016/j.molimm.2015.04.019
M3 - Review article
C2 - 25979818
AN - SCOPUS:84955632443
SN - 0161-5890
VL - 68
SP - 68
EP - 71
JO - Molecular Immunology
JF - Molecular Immunology
IS - 2
ER -