PLACE DE LA CHIMIOTHERAPIE A HAUTES DOSES SUIVIE D'AUTOGREFFE MEDULLAIRE DANS LE TRAITEMENT DES SARCOMES D'EWING METASTATIQUES DE L'ENFANT

O. Hartmann; O. Oberlin; F. Beaujean; L. Brugieres; D. Valteau; G. Vassal; J. Lemerle

PLACE DE LA CHIMIOTHERAPIE A HAUTES DOSES SUIVIE D'AUTOGREFFE MEDULLAIRE DANS LE TRAITEMENT DES SARCOMES D'EWING METASTATIQUES DE L'ENFANT

O. Hartmann, O. Oberlin, F. Beaujean, L. Brugieres, D. Valteau, G. Vassal, J. Lemerle

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Résumé

Thirty-two children were treated for metastatic Ewing sarcoma by high-dose chemotherapy followed by autologous bone marrow transplantation. Fourteen patients entered phase II studies of high-dose alkylating agents. The response rate observed was 61%. High-dose chemotherapy was used as consolidation in complete remission of 18 patients. Disease free survival appears to be better than that observed under conventional altered chemotherapy. However, with only 4/18 long term survivors, these results remain unsatisfactory, taking into account the recent encouraging results of semi-continuous conventional chemotherapy.

Titre traduit de la contribution	High-dose chemotherapy followed by autologous bone marrow transplantation in children's metastatic Ewing sarcoma
langue originale	Français
Pages (de - à)	181-187
Nombre de pages	7
journal	Bulletin du Cancer
Volume	77
Numéro de publication	2
état	Publié - 1 janv. 1990

mots-clés

Bone marrow transplantation
Child
Ewing sarcoma
High-dose chemotherapy

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title = "PLACE DE LA CHIMIOTHERAPIE A HAUTES DOSES SUIVIE D'AUTOGREFFE MEDULLAIRE DANS LE TRAITEMENT DES SARCOMES D'EWING METASTATIQUES DE L'ENFANT",

abstract = "Thirty-two children were treated for metastatic Ewing sarcoma by high-dose chemotherapy followed by autologous bone marrow transplantation. Fourteen patients entered phase II studies of high-dose alkylating agents. The response rate observed was 61%. High-dose chemotherapy was used as consolidation in complete remission of 18 patients. Disease free survival appears to be better than that observed under conventional altered chemotherapy. However, with only 4/18 long term survivors, these results remain unsatisfactory, taking into account the recent encouraging results of semi-continuous conventional chemotherapy.",

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year = "1990",

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T1 - PLACE DE LA CHIMIOTHERAPIE A HAUTES DOSES SUIVIE D'AUTOGREFFE MEDULLAIRE DANS LE TRAITEMENT DES SARCOMES D'EWING METASTATIQUES DE L'ENFANT

AU - Hartmann, O.

AU - Oberlin, O.

AU - Beaujean, F.

AU - Brugieres, L.

AU - Valteau, D.

AU - Vassal, G.

AU - Lemerle, J.

PY - 1990/1/1

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N2 - Thirty-two children were treated for metastatic Ewing sarcoma by high-dose chemotherapy followed by autologous bone marrow transplantation. Fourteen patients entered phase II studies of high-dose alkylating agents. The response rate observed was 61%. High-dose chemotherapy was used as consolidation in complete remission of 18 patients. Disease free survival appears to be better than that observed under conventional altered chemotherapy. However, with only 4/18 long term survivors, these results remain unsatisfactory, taking into account the recent encouraging results of semi-continuous conventional chemotherapy.

AB - Thirty-two children were treated for metastatic Ewing sarcoma by high-dose chemotherapy followed by autologous bone marrow transplantation. Fourteen patients entered phase II studies of high-dose alkylating agents. The response rate observed was 61%. High-dose chemotherapy was used as consolidation in complete remission of 18 patients. Disease free survival appears to be better than that observed under conventional altered chemotherapy. However, with only 4/18 long term survivors, these results remain unsatisfactory, taking into account the recent encouraging results of semi-continuous conventional chemotherapy.

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KW - Child

KW - Ewing sarcoma

KW - High-dose chemotherapy

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